Differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety-like behavior and Fos immunoreactivity in the lateral septal nucleus in rats
The aim of this study was to compare the effects of acute (a single injection) and chronic (21 consecutive days) treatments with chrysin 2, 4, and 8 μmol kg−1 on anxiety-like behavior and Fos immunoreactivity in the lateral septum nucleus (LSN), a structure that is involved in the regulation of anxi...
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| Format: | Article |
| Language: | English |
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Sciendo
2020-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2020-0022 |
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| author | Germán-Ponciano León Jesús Puga-Olguín Abraham De Jesús Rovirosa-Hernández María Caba Mario Meza Enrique Rodríguez-Landa Juan Francisco |
| author_facet | Germán-Ponciano León Jesús Puga-Olguín Abraham De Jesús Rovirosa-Hernández María Caba Mario Meza Enrique Rodríguez-Landa Juan Francisco |
| author_sort | Germán-Ponciano León Jesús |
| collection | DOAJ |
| description | The aim of this study was to compare the effects of acute (a single injection) and chronic (21 consecutive days) treatments with chrysin 2, 4, and 8 μmol kg−1 on anxiety-like behavior and Fos immunoreactivity in the lateral septum nucleus (LSN), a structure that is involved in the regulation of anxiety, in male Wistar rats. These effects were compared with the clinically effective anxiolytic diazepam 7 μmol kg−1. The results showed that acute, but not chronic treatment, with 4 μmol kg−1 chrysin exerted anxiolytic- and anti- depressant-like effects with these effects being similar to that of diazepam. Also, none of the above-mentioned treatments did alter Fos immunoreactivity in the LSN, but a tendency towards the reduction of this variable was detected with chrysin 4 μmol kg−1 and diazepam 7 μmol kg−1. Altogether, results suggest that chrysin exerts anxiolytic-like effects, however, it can produce pharmacological tolerance after repeated use, similar to benzodiazepines. |
| format | Article |
| id | doaj-art-32c4ae976c2e4867ac6f32269d39d4b2 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-32c4ae976c2e4867ac6f32269d39d4b22025-02-02T10:48:07ZengSciendoActa Pharmaceutica1846-95582020-09-0170338739710.2478/acph-2020-0022acph-2020-0022Differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety-like behavior and Fos immunoreactivity in the lateral septal nucleus in ratsGermán-Ponciano León Jesús0Puga-Olguín Abraham1De Jesús Rovirosa-Hernández María2Caba Mario3Meza Enrique4Rodríguez-Landa Juan Francisco5Programa de Posgrado en Neuroetología Instituto de Neuroetología, Universidad Veracruzana, Xalapa91190, Veracruz, MéxicoPrograma de Posgrado en Neuroetología Instituto de Neuroetología, Universidad Veracruzana, Xalapa91190, Veracruz, MéxicoInstituto de Neuroetología, Universidad Veracruzana, Xalapa91190, Veracruz, MéxicoCentro de Investigaciones Biomédicas Universidad Veracruzana, Xalapa91190 Veracruz, MéxicoCentro de Investigaciones Biomédicas Universidad Veracruzana, Xalapa91190 Veracruz, MéxicoLaboratorio de Neurofarmacología Instituto de Neuroetología, Universidad Veracruzana, Xalapa91190, Veracruz, MéxicoThe aim of this study was to compare the effects of acute (a single injection) and chronic (21 consecutive days) treatments with chrysin 2, 4, and 8 μmol kg−1 on anxiety-like behavior and Fos immunoreactivity in the lateral septum nucleus (LSN), a structure that is involved in the regulation of anxiety, in male Wistar rats. These effects were compared with the clinically effective anxiolytic diazepam 7 μmol kg−1. The results showed that acute, but not chronic treatment, with 4 μmol kg−1 chrysin exerted anxiolytic- and anti- depressant-like effects with these effects being similar to that of diazepam. Also, none of the above-mentioned treatments did alter Fos immunoreactivity in the LSN, but a tendency towards the reduction of this variable was detected with chrysin 4 μmol kg−1 and diazepam 7 μmol kg−1. Altogether, results suggest that chrysin exerts anxiolytic-like effects, however, it can produce pharmacological tolerance after repeated use, similar to benzodiazepines.https://doi.org/10.2478/acph-2020-0022chrysinanxiolyticelevated plus mazefos proteinlateral septal nucleus |
| spellingShingle | Germán-Ponciano León Jesús Puga-Olguín Abraham De Jesús Rovirosa-Hernández María Caba Mario Meza Enrique Rodríguez-Landa Juan Francisco Differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety-like behavior and Fos immunoreactivity in the lateral septal nucleus in rats Acta Pharmaceutica chrysin anxiolytic elevated plus maze fos protein lateral septal nucleus |
| title | Differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety-like behavior and Fos immunoreactivity in the lateral septal nucleus in rats |
| title_full | Differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety-like behavior and Fos immunoreactivity in the lateral septal nucleus in rats |
| title_fullStr | Differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety-like behavior and Fos immunoreactivity in the lateral septal nucleus in rats |
| title_full_unstemmed | Differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety-like behavior and Fos immunoreactivity in the lateral septal nucleus in rats |
| title_short | Differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety-like behavior and Fos immunoreactivity in the lateral septal nucleus in rats |
| title_sort | differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety like behavior and fos immunoreactivity in the lateral septal nucleus in rats |
| topic | chrysin anxiolytic elevated plus maze fos protein lateral septal nucleus |
| url | https://doi.org/10.2478/acph-2020-0022 |
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