Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover study
Background The subcallosal cingulate gyrus (SCG) is integral to cognitive function and mood regulation. Open-label SCG deep brain stimulation (DBS) studies demonstrate improvement or stabilisation of cognitive function in treatment-resistant depression (TRD).Objective This randomised controlled stud...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2025-02-01
|
| Series: | BMJ Mental Health |
| Online Access: | https://mentalhealth.bmj.com/content/28/1/e301408.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850204939334189056 |
|---|---|
| author | Andres M Lozano Wendy Lou Peter Giacobbe Sidney H Kennedy Michelle Wu Vanessa K Tassone Venkat Bhat Fatemeh Gholamali Nezhad Yuelee Khoo Qiaowei Lin Ilya Demchenko Reinhard Janssen-Aguilar Amanda K Ceniti Sakina J Rizvi Mary Pat McAndrews |
| author_facet | Andres M Lozano Wendy Lou Peter Giacobbe Sidney H Kennedy Michelle Wu Vanessa K Tassone Venkat Bhat Fatemeh Gholamali Nezhad Yuelee Khoo Qiaowei Lin Ilya Demchenko Reinhard Janssen-Aguilar Amanda K Ceniti Sakina J Rizvi Mary Pat McAndrews |
| author_sort | Andres M Lozano |
| collection | DOAJ |
| description | Background The subcallosal cingulate gyrus (SCG) is integral to cognitive function and mood regulation. Open-label SCG deep brain stimulation (DBS) studies demonstrate improvement or stabilisation of cognitive function in treatment-resistant depression (TRD).Objective This randomised controlled study aims to evaluate the neuropsychological effects of SCG-DBS.Methods 35 participants with TRD received active or sham stimulation over two 3-month periods. A neuropsychological battery was administered to assess processing speed, learning and memory, and cognitive flexibility. Composite measures were derived for each domain after Period I. A mixed model for repeated measures analysis was performed for each test, with further analysis of significant measures to determine sustainability after Period II.Findings No significant differences in changes in depression scores were observed between groups. There were no significant deteriorations in cognitive performance following active SCG-DBS. Category Fluency Test performance improved after 3 months of active SCG-DBS (p=0.002); however, this was non-significant after correcting for multiple comparisons and was not observed after Period II (p=0.615).Conclusion and implications While no cognitive deterioration was observed following SCG-DBS, significant improvements in cognitive function were not evident. There may be a transient enhancement in processing speed; however, this effect is not fully understood. Future studies should include larger cohorts and extended stimulation periods to explore the long-term effects of SCG-DBS in TRD and the sustainability of improvements in cognitive domains. |
| format | Article |
| id | doaj-art-32c232bd245e4fac9ec04e73514b9f30 |
| institution | OA Journals |
| issn | 2755-9734 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Mental Health |
| spelling | doaj-art-32c232bd245e4fac9ec04e73514b9f302025-08-20T02:11:12ZengBMJ Publishing GroupBMJ Mental Health2755-97342025-02-0128110.1136/bmjment-2024-301408Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover studyAndres M Lozano0Wendy Lou1Peter Giacobbe2Sidney H Kennedy3Michelle Wu4Vanessa K Tassone5Venkat Bhat6Fatemeh Gholamali Nezhad7Yuelee Khoo8Qiaowei Lin9Ilya Demchenko10Reinhard Janssen-Aguilar11Amanda K Ceniti12Sakina J Rizvi13Mary Pat McAndrews14Division of Neurosurgery, Department of Surgery, University Health Network and University of Toronto, Toronto, Ontario, CanadaDivision of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, CanadaSunnybrook Research Institute, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, CanadaInstitute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaInterventional Psychiatry Program, St Michael’s Hospital, Unity Health Toronto, Toronto, Ontario, CanadaInterventional Psychiatry Program, St Michael’s Hospital, Unity Health Toronto, Toronto, Ontario, CanadaKrembil Research Institute, University of Toronto, Toronto, Ontario, CanadaInterventional Psychiatry Program, St Michael’s Hospital, Unity Health Toronto, Toronto, Ontario, CanadaInterventional Psychiatry Program, St Michael’s Hospital, Unity Health Toronto, Toronto, Ontario, CanadaInterventional Psychiatry Program, St Michael’s Hospital, Unity Health Toronto, Toronto, Ontario, CanadaInterventional Psychiatry Program, St Michael’s Hospital, Unity Health Toronto, Toronto, Ontario, CanadaInterventional Psychiatry Program, St Michael’s Hospital, Unity Health Toronto, Toronto, Ontario, CanadaArthur Sommer Rotenberg Suicide and Depression Studies Program, St Michael’s Hospital, Toronto, Ontario, CanadaInstitute of Medical Science, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, CanadaKrembil Research Institute, University of Toronto, Toronto, Ontario, CanadaBackground The subcallosal cingulate gyrus (SCG) is integral to cognitive function and mood regulation. Open-label SCG deep brain stimulation (DBS) studies demonstrate improvement or stabilisation of cognitive function in treatment-resistant depression (TRD).Objective This randomised controlled study aims to evaluate the neuropsychological effects of SCG-DBS.Methods 35 participants with TRD received active or sham stimulation over two 3-month periods. A neuropsychological battery was administered to assess processing speed, learning and memory, and cognitive flexibility. Composite measures were derived for each domain after Period I. A mixed model for repeated measures analysis was performed for each test, with further analysis of significant measures to determine sustainability after Period II.Findings No significant differences in changes in depression scores were observed between groups. There were no significant deteriorations in cognitive performance following active SCG-DBS. Category Fluency Test performance improved after 3 months of active SCG-DBS (p=0.002); however, this was non-significant after correcting for multiple comparisons and was not observed after Period II (p=0.615).Conclusion and implications While no cognitive deterioration was observed following SCG-DBS, significant improvements in cognitive function were not evident. There may be a transient enhancement in processing speed; however, this effect is not fully understood. Future studies should include larger cohorts and extended stimulation periods to explore the long-term effects of SCG-DBS in TRD and the sustainability of improvements in cognitive domains.https://mentalhealth.bmj.com/content/28/1/e301408.full |
| spellingShingle | Andres M Lozano Wendy Lou Peter Giacobbe Sidney H Kennedy Michelle Wu Vanessa K Tassone Venkat Bhat Fatemeh Gholamali Nezhad Yuelee Khoo Qiaowei Lin Ilya Demchenko Reinhard Janssen-Aguilar Amanda K Ceniti Sakina J Rizvi Mary Pat McAndrews Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover study BMJ Mental Health |
| title | Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover study |
| title_full | Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover study |
| title_fullStr | Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover study |
| title_full_unstemmed | Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover study |
| title_short | Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover study |
| title_sort | lack of neuropsychological effects following short term subcallosal cingulate gyrus deep brain stimulation in treatment resistant depression a randomised crossover study |
| url | https://mentalhealth.bmj.com/content/28/1/e301408.full |
| work_keys_str_mv | AT andresmlozano lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy AT wendylou lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy AT petergiacobbe lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy AT sidneyhkennedy lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy AT michellewu lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy AT vanessaktassone lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy AT venkatbhat lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy AT fatemehgholamalinezhad lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy AT yueleekhoo lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy AT qiaoweilin lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy AT ilyademchenko lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy AT reinhardjanssenaguilar lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy AT amandakceniti lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy AT sakinajrizvi lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy AT marypatmcandrews lackofneuropsychologicaleffectsfollowingshorttermsubcallosalcingulategyrusdeepbrainstimulationintreatmentresistantdepressionarandomisedcrossoverstudy |