Hemophilia B With Intracranial Hemorrhage Rehabilitation in High‐Dependency Unit: A Case Report
ABSTRACT Hemophilia B, an X‐linked recessive coagulation disorder, poses significant risks of life‐threatening intracranial hemorrhage (ICH). This case report details the multidisciplinary rehabilitation of a 41‐year‐old male with moderate hemophilia B (FIX activity: 3.9%) and ICH in a resource‐limi...
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.70470 |
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| author | Xiaoyan Feng Hongjun Zhu Liying Han Hongxing Xu Lei He |
| author_facet | Xiaoyan Feng Hongjun Zhu Liying Han Hongxing Xu Lei He |
| author_sort | Xiaoyan Feng |
| collection | DOAJ |
| description | ABSTRACT Hemophilia B, an X‐linked recessive coagulation disorder, poses significant risks of life‐threatening intracranial hemorrhage (ICH). This case report details the multidisciplinary rehabilitation of a 41‐year‐old male with moderate hemophilia B (FIX activity: 3.9%) and ICH in a resource‐limited setting. Admitted to a high‐dependency unit postneurosurgical intervention, the patient received low‐dose prophylactic coagulation factor IX (maintained at 34.6%–66.2%) alongside real‐time coagulation monitoring. A stepwise rehabilitation protocol was implemented, including early passive joint mobilization, neuromuscular electrical stimulation, and progressive task‐oriented training, tailored to minimize bleeding risk. Over 7 weeks, the patient achieved marked functional improvement: Activity of Daily Living score increased from 0 to 80, modified Rankin Scale improved from 5 to 3, and Fugl‐Meyer Assessment (FMA) rose from 0 to 60, with no secondary bleeding. This case highlights the feasibility of integrating low‐dose prophylaxis with early rehabilitation in developing countries, offering a cost‐effective model to enhance functional recovery and reduce disability in hemophilia‐related ICH. |
| format | Article |
| id | doaj-art-32c1ac06cd834a6684888544d2d65b31 |
| institution | DOAJ |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-32c1ac06cd834a6684888544d2d65b312025-08-20T03:15:05ZengWileyClinical Case Reports2050-09042025-04-01134n/an/a10.1002/ccr3.70470Hemophilia B With Intracranial Hemorrhage Rehabilitation in High‐Dependency Unit: A Case ReportXiaoyan Feng0Hongjun Zhu1Liying Han2Hongxing Xu3Lei He4Department of Physical Medicine & Rehabilitation The First Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Physical Medicine & Rehabilitation The First Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Physical Medicine & Rehabilitation The First Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Physical Medicine & Rehabilitation The First Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaDepartment of Physical Medicine & Rehabilitation The First Affiliated Hospital of Soochow University Suzhou Jiangsu ChinaABSTRACT Hemophilia B, an X‐linked recessive coagulation disorder, poses significant risks of life‐threatening intracranial hemorrhage (ICH). This case report details the multidisciplinary rehabilitation of a 41‐year‐old male with moderate hemophilia B (FIX activity: 3.9%) and ICH in a resource‐limited setting. Admitted to a high‐dependency unit postneurosurgical intervention, the patient received low‐dose prophylactic coagulation factor IX (maintained at 34.6%–66.2%) alongside real‐time coagulation monitoring. A stepwise rehabilitation protocol was implemented, including early passive joint mobilization, neuromuscular electrical stimulation, and progressive task‐oriented training, tailored to minimize bleeding risk. Over 7 weeks, the patient achieved marked functional improvement: Activity of Daily Living score increased from 0 to 80, modified Rankin Scale improved from 5 to 3, and Fugl‐Meyer Assessment (FMA) rose from 0 to 60, with no secondary bleeding. This case highlights the feasibility of integrating low‐dose prophylaxis with early rehabilitation in developing countries, offering a cost‐effective model to enhance functional recovery and reduce disability in hemophilia‐related ICH.https://doi.org/10.1002/ccr3.70470hemophilia Bhigh‐dependency unitintracranial hemorrhagerehabilitation |
| spellingShingle | Xiaoyan Feng Hongjun Zhu Liying Han Hongxing Xu Lei He Hemophilia B With Intracranial Hemorrhage Rehabilitation in High‐Dependency Unit: A Case Report Clinical Case Reports hemophilia B high‐dependency unit intracranial hemorrhage rehabilitation |
| title | Hemophilia B With Intracranial Hemorrhage Rehabilitation in High‐Dependency Unit: A Case Report |
| title_full | Hemophilia B With Intracranial Hemorrhage Rehabilitation in High‐Dependency Unit: A Case Report |
| title_fullStr | Hemophilia B With Intracranial Hemorrhage Rehabilitation in High‐Dependency Unit: A Case Report |
| title_full_unstemmed | Hemophilia B With Intracranial Hemorrhage Rehabilitation in High‐Dependency Unit: A Case Report |
| title_short | Hemophilia B With Intracranial Hemorrhage Rehabilitation in High‐Dependency Unit: A Case Report |
| title_sort | hemophilia b with intracranial hemorrhage rehabilitation in high dependency unit a case report |
| topic | hemophilia B high‐dependency unit intracranial hemorrhage rehabilitation |
| url | https://doi.org/10.1002/ccr3.70470 |
| work_keys_str_mv | AT xiaoyanfeng hemophiliabwithintracranialhemorrhagerehabilitationinhighdependencyunitacasereport AT hongjunzhu hemophiliabwithintracranialhemorrhagerehabilitationinhighdependencyunitacasereport AT liyinghan hemophiliabwithintracranialhemorrhagerehabilitationinhighdependencyunitacasereport AT hongxingxu hemophiliabwithintracranialhemorrhagerehabilitationinhighdependencyunitacasereport AT leihe hemophiliabwithintracranialhemorrhagerehabilitationinhighdependencyunitacasereport |