Urinary Equol and Equol‐Predicting Microbial Species Are Favorably Associated With Cardiometabolic Risk Markers in Chinese Adults
Background The association between soy isoflavones intake and cardiometabolic health remains inconclusive. We investigated the associations of urinary biomarkers of isoflavones including daidzein, glycitein, genistein, equol (a gut microbial metabolite of daidzein), and equol‐predicting microbial sp...
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Wiley
2024-07-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.034126 |
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| author | Shaoxian Liang Honghua Zhang Yufeng Mo Yamin Li Xiaoyu Zhang Hongjuan Cao Shaoyu Xie Danni Wang Yaning Lv Yaqin Wu Zhuang Zhang Wanshui Yang |
| author_facet | Shaoxian Liang Honghua Zhang Yufeng Mo Yamin Li Xiaoyu Zhang Hongjuan Cao Shaoyu Xie Danni Wang Yaning Lv Yaqin Wu Zhuang Zhang Wanshui Yang |
| author_sort | Shaoxian Liang |
| collection | DOAJ |
| description | Background The association between soy isoflavones intake and cardiometabolic health remains inconclusive. We investigated the associations of urinary biomarkers of isoflavones including daidzein, glycitein, genistein, equol (a gut microbial metabolite of daidzein), and equol‐predicting microbial species with cardiometabolic risk markers. Methods and Results In a 1‐year study of 305 Chinese community‐dwelling adults aged ≥18 years, urinary isoflavones, fecal microbiota, blood pressure, blood glucose and lipids, and anthropometric data were measured twice, 1 year apart. Brachial‐ankle pulse wave velocity was also measured after 1 year. A linear mixed‐effects model was used to analyze repeated measurements. Logistic regression was used to calculate the adjusted odds ratio (aOR) and 95% CI for the associations for arterial stiffness. Each 1 μg/g creatinine increase in urinary equol concentrations was associated with 1.47%, 0.96%, and 3.32% decrease in triglycerides, plasma atherogenic index, and metabolic syndrome score, respectively (all P<0.05), and 0.61% increase in high‐density lipoprotein cholesterol (P=0.025). Urinary equol was also associated with lower risk of arterial stiffness (aOR, 0.28 [95% CI, 0.09–0.90]; Ptrend=0.036). We identified 21 bacterial genera whose relative abundance was positively associated with urinary equol (false discovery rate‐corrected P<0.05) and constructed a microbial species score to reflect the overall equol‐predicting capacity. This score (per 1‐point increase) was inversely associated with triglycerides (percentage difference=−1.48%), plasma atherogenic index (percentage difference=−0.85%), and the risk of arterial stiffness (aOR, 0.27 [95% CI, 0.08–0.88]; all P<0.05). Conclusions Our findings suggest that urinary equol and equol‐predicting microbial species may improve cardiometabolic risk parameters in Chinese adults. |
| format | Article |
| id | doaj-art-32bfe8bd990d4eaea991beb26e2cdf57 |
| institution | OA Journals |
| issn | 2047-9980 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Wiley |
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| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj-art-32bfe8bd990d4eaea991beb26e2cdf572025-08-20T02:26:33ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802024-07-01131310.1161/JAHA.123.034126Urinary Equol and Equol‐Predicting Microbial Species Are Favorably Associated With Cardiometabolic Risk Markers in Chinese AdultsShaoxian Liang0Honghua Zhang1Yufeng Mo2Yamin Li3Xiaoyu Zhang4Hongjuan Cao5Shaoyu Xie6Danni Wang7Yaning Lv8Yaqin Wu9Zhuang Zhang10Wanshui Yang11Department of Nutrition, Center for Big Data and Population Health of IHM School of Public Health, Anhui Medical University Hefei Anhui ChinaDepartment of Nutrition, Center for Big Data and Population Health of IHM School of Public Health, Anhui Medical University Hefei Anhui ChinaDepartment of Nutrition, Center for Big Data and Population Health of IHM School of Public Health, Anhui Medical University Hefei Anhui ChinaDepartment of Nutrition, Center for Big Data and Population Health of IHM School of Public Health, Anhui Medical University Hefei Anhui ChinaDepartment of Physical Examination Center The First Affiliated Hospital of Anhui Medical University Hefei Anhui ChinaDepartment of Chronic Noncommunicable Diseases Prevention and Control Lu’an Municipal Center for Disease Control and Prevention Lu’an Anhui ChinaDepartment of Chronic Noncommunicable Diseases Prevention and Control Lu’an Municipal Center for Disease Control and Prevention Lu’an Anhui ChinaDepartment of Nutrition, Center for Big Data and Population Health of IHM School of Public Health, Anhui Medical University Hefei Anhui ChinaTechnology Center of Hefei Customs, and Anhui Province Key Laboratory of Analysis and Detection for Food Safety Hefei Anhui ChinaTechnology Center of Hefei Customs, and Anhui Province Key Laboratory of Analysis and Detection for Food Safety Hefei Anhui ChinaDepartment of Nutrition, Center for Big Data and Population Health of IHM School of Public Health, Anhui Medical University Hefei Anhui ChinaDepartment of Nutrition, Center for Big Data and Population Health of IHM School of Public Health, Anhui Medical University Hefei Anhui ChinaBackground The association between soy isoflavones intake and cardiometabolic health remains inconclusive. We investigated the associations of urinary biomarkers of isoflavones including daidzein, glycitein, genistein, equol (a gut microbial metabolite of daidzein), and equol‐predicting microbial species with cardiometabolic risk markers. Methods and Results In a 1‐year study of 305 Chinese community‐dwelling adults aged ≥18 years, urinary isoflavones, fecal microbiota, blood pressure, blood glucose and lipids, and anthropometric data were measured twice, 1 year apart. Brachial‐ankle pulse wave velocity was also measured after 1 year. A linear mixed‐effects model was used to analyze repeated measurements. Logistic regression was used to calculate the adjusted odds ratio (aOR) and 95% CI for the associations for arterial stiffness. Each 1 μg/g creatinine increase in urinary equol concentrations was associated with 1.47%, 0.96%, and 3.32% decrease in triglycerides, plasma atherogenic index, and metabolic syndrome score, respectively (all P<0.05), and 0.61% increase in high‐density lipoprotein cholesterol (P=0.025). Urinary equol was also associated with lower risk of arterial stiffness (aOR, 0.28 [95% CI, 0.09–0.90]; Ptrend=0.036). We identified 21 bacterial genera whose relative abundance was positively associated with urinary equol (false discovery rate‐corrected P<0.05) and constructed a microbial species score to reflect the overall equol‐predicting capacity. This score (per 1‐point increase) was inversely associated with triglycerides (percentage difference=−1.48%), plasma atherogenic index (percentage difference=−0.85%), and the risk of arterial stiffness (aOR, 0.27 [95% CI, 0.08–0.88]; all P<0.05). Conclusions Our findings suggest that urinary equol and equol‐predicting microbial species may improve cardiometabolic risk parameters in Chinese adults.https://www.ahajournals.org/doi/10.1161/JAHA.123.034126cardiometabolic riskequolgut microbiomeisoflavonesrepeated measurements |
| spellingShingle | Shaoxian Liang Honghua Zhang Yufeng Mo Yamin Li Xiaoyu Zhang Hongjuan Cao Shaoyu Xie Danni Wang Yaning Lv Yaqin Wu Zhuang Zhang Wanshui Yang Urinary Equol and Equol‐Predicting Microbial Species Are Favorably Associated With Cardiometabolic Risk Markers in Chinese Adults Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiometabolic risk equol gut microbiome isoflavones repeated measurements |
| title | Urinary Equol and Equol‐Predicting Microbial Species Are Favorably Associated With Cardiometabolic Risk Markers in Chinese Adults |
| title_full | Urinary Equol and Equol‐Predicting Microbial Species Are Favorably Associated With Cardiometabolic Risk Markers in Chinese Adults |
| title_fullStr | Urinary Equol and Equol‐Predicting Microbial Species Are Favorably Associated With Cardiometabolic Risk Markers in Chinese Adults |
| title_full_unstemmed | Urinary Equol and Equol‐Predicting Microbial Species Are Favorably Associated With Cardiometabolic Risk Markers in Chinese Adults |
| title_short | Urinary Equol and Equol‐Predicting Microbial Species Are Favorably Associated With Cardiometabolic Risk Markers in Chinese Adults |
| title_sort | urinary equol and equol predicting microbial species are favorably associated with cardiometabolic risk markers in chinese adults |
| topic | cardiometabolic risk equol gut microbiome isoflavones repeated measurements |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.034126 |
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