Modulation of oxidative stress/NMDA/nitric oxide pathway by topiramate attenuates morphine dependence in mice

Modulation of oxidative stress/NMDA/nitric oxide pathway by topiramate attenuates morphine dependence in mice

Morphine belongs to the class of opioids and is known for its potential to cause dependence and addiction, particularly with prolonged use. Due to the associated risks, caution must be taken when prescribing and limiting its clinical use. Overexpression of N-methyl-D-aspartate (NMDA) receptors, nitr...

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Bibliographic Details
Main Authors: Shabir Hussain, Haji Bahadar, Muhammad Imran Khan, Neelum Gul Qazi, Shabnum Gul Wazir, Habab Ali Ahmad
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Morphine
NMDA
Nitric oxide
MK-801
Dependence
Oxidative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024166157
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