Sphingosine-1-phosphate stimulates colorectal cancer tumor microenvironment angiogenesis and induces macrophage polarization via macrophage migration inhibitory factor

Sphingosine-1-phosphate stimulates colorectal cancer tumor microenvironment angiogenesis and induces macrophage polarization via macrophage migration inhibitory factor

BackgroundColorectal cancer (CRC) is the most common gastrointestinal malignancy with extensive reprogramming of sphingolipid metabolism. However, the role and mechanisms of sphingosine-1-phosphate (S1P), a key bioactive molecule in sphingolipid metabolism, remain insufficiently characterized. There...

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Bibliographic Details
Main Authors: Fang Wu, Zhaode Feng, Xuan Wang, Yingcong Guo, Bingcong Wu, Shuheng Bai, Ning Lan, Min Chen, Juan Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
sphingosine-1-phosphate
tumor-associated macrophages polarization
angiogenesis
colorectal cancer
scRNA-seq
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1564213/full
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