New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine
Following the application of epigenetic and epigenomics research into tumor diseases, cardiovascular disease, diabetes, hereditary diseases, and rare diseases, in vitro diagnostics (IVD) epigenetic and epigenomics are increasingly employed for those patients. Here, we review a clinical sampling of e...
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MDPI AG
2025-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/12/1539 |
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| author | Pengtao Song Biaoru Li |
| author_facet | Pengtao Song Biaoru Li |
| author_sort | Pengtao Song |
| collection | DOAJ |
| description | Following the application of epigenetic and epigenomics research into tumor diseases, cardiovascular disease, diabetes, hereditary diseases, and rare diseases, in vitro diagnostics (IVD) epigenetic and epigenomics are increasingly employed for those patients. Here, we review a clinical sampling of epigenetics and epigenomics from patients. We then present procedures, including the detection procedure of clinical epigenetic approaches from clinical samples, clinical epigenomic methods applied to those samples, the small cell number of epigenetics, and epigenomics. Finally, we present the current IVD of epigenetics and epigenomics used for clinical analysis and diagnosis, along with the development of approaches. To improve clinical study and diagnosis, we also introduce clinical research and clinical applications to develop a more comprehensive strategy to maximize the sensitivity and specificity of the epigenetics and epigenomics analysis and diagnosis. |
| format | Article |
| id | doaj-art-32b1ab488b54469e86ad2ee78de5ce16 |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-32b1ab488b54469e86ad2ee78de5ce162025-08-20T02:24:25ZengMDPI AGDiagnostics2075-44182025-06-011512153910.3390/diagnostics15121539New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision MedicinePengtao Song0Biaoru Li1Department of Pathology, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Affiliated Central Hospital of Huzhou University, Huzhou 313000, ChinaSchool of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USAFollowing the application of epigenetic and epigenomics research into tumor diseases, cardiovascular disease, diabetes, hereditary diseases, and rare diseases, in vitro diagnostics (IVD) epigenetic and epigenomics are increasingly employed for those patients. Here, we review a clinical sampling of epigenetics and epigenomics from patients. We then present procedures, including the detection procedure of clinical epigenetic approaches from clinical samples, clinical epigenomic methods applied to those samples, the small cell number of epigenetics, and epigenomics. Finally, we present the current IVD of epigenetics and epigenomics used for clinical analysis and diagnosis, along with the development of approaches. To improve clinical study and diagnosis, we also introduce clinical research and clinical applications to develop a more comprehensive strategy to maximize the sensitivity and specificity of the epigenetics and epigenomics analysis and diagnosis.https://www.mdpi.com/2075-4418/15/12/1539epigeneticsepigenomicsin vitro diagnostics (IVD)single-cell diagnosis |
| spellingShingle | Pengtao Song Biaoru Li New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine Diagnostics epigenetics epigenomics in vitro diagnostics (IVD) single-cell diagnosis |
| title | New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine |
| title_full | New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine |
| title_fullStr | New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine |
| title_full_unstemmed | New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine |
| title_short | New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine |
| title_sort | new generation of clinical epigenetics analysis and diagnosis for precision medicine |
| topic | epigenetics epigenomics in vitro diagnostics (IVD) single-cell diagnosis |
| url | https://www.mdpi.com/2075-4418/15/12/1539 |
| work_keys_str_mv | AT pengtaosong newgenerationofclinicalepigeneticsanalysisanddiagnosisforprecisionmedicine AT biaoruli newgenerationofclinicalepigeneticsanalysisanddiagnosisforprecisionmedicine |