Spatial characterization of tertiary lymphoid structures as predictive biomarkers for immune checkpoint blockade in head and neck squamous cell carcinoma

Spatial characterization of tertiary lymphoid structures as predictive biomarkers for immune checkpoint blockade in head and neck squamous cell carcinoma

Immune checkpoint blockade (ICB) is the standard of care for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC), yet efficacy remains low. The combined positive score (CPS) for PD-L1 is the only biomarker approved to predict response to ICB and has limited performance. Tertiary Lymph...

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Bibliographic Details
Main Authors: Daniel A. Ruiz-Torres, Michael E. Bryan, Shun Hirayama, Ross D. Merkin, Evelyn Luciani, Thomas J. Roberts, Manisha Patel, Jong C. Park, Lori J. Wirth, Peter M. Sadow, Moshe Sade-Feldman, Shannon L. Stott, Daniel L. Faden
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Head and neck cancer
immune checkpoint blockade
spatial biology
tertiary lymphoid structures
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2466308
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