The role of stem cells in the recovery of hemopoiesis in cytostatic and radial myelosuppressions
The development of hemopoietic tissue hypoplasia and recovery of hemopoietic dynamics in addition to the direct suppressive effect of toxic agents on hemopoietic cells are mainly due to the character of hemopoietic disregulation were shown on different models of myelosuppressions (irradiation, injec...
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| Format: | Article |
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Siberian State Medical University (Tomsk)
2006-06-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/3063 |
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| author | Ye. D. Goldberg A. M. Dygai V. V. Zhdanov |
| author_facet | Ye. D. Goldberg A. M. Dygai V. V. Zhdanov |
| author_sort | Ye. D. Goldberg |
| collection | DOAJ |
| description | The development of hemopoietic tissue hypoplasia and recovery of hemopoietic dynamics in addition to the direct suppressive effect of toxic agents on hemopoietic cells are mainly due to the character of hemopoietic disregulation were shown on different models of myelosuppressions (irradiation, injecting cytostatic drugs having different action mechanisms). At the same time, compensatory changes of blood system and underlying mechanisms are mainly non-specific and of the same type. Creation of reparative processes in the hemopoietic tissue is significantly by bone marrow stromal cells thanks to chemioand radioresistance of their precursors (mesenchimal stem cells). |
| format | Article |
| id | doaj-art-32af574c1c434c4ebeaa9b4de2deba89 |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2006-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-32af574c1c434c4ebeaa9b4de2deba892025-08-20T03:02:23ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842006-06-0152354210.20538/1682-0363-2006-2-35-421721The role of stem cells in the recovery of hemopoiesis in cytostatic and radial myelosuppressionsYe. D. Goldberg0A. M. Dygai1V. V. Zhdanov2НИИ фармакологии ТНЦ СО РАМННИИ фармакологии ТНЦ СО РАМННИИ фармакологии ТНЦ СО РАМНThe development of hemopoietic tissue hypoplasia and recovery of hemopoietic dynamics in addition to the direct suppressive effect of toxic agents on hemopoietic cells are mainly due to the character of hemopoietic disregulation were shown on different models of myelosuppressions (irradiation, injecting cytostatic drugs having different action mechanisms). At the same time, compensatory changes of blood system and underlying mechanisms are mainly non-specific and of the same type. Creation of reparative processes in the hemopoietic tissue is significantly by bone marrow stromal cells thanks to chemioand radioresistance of their precursors (mesenchimal stem cells).https://bulletin.ssmu.ru/jour/article/view/3063миелосупрессиирегенерациястволовые кроветворные клеткимезенхимальные стволовые клеткиоблучениеmielosuppressionsregenerationstem hemopoietic cellsmesenchimal stem cellsirradiation |
| spellingShingle | Ye. D. Goldberg A. M. Dygai V. V. Zhdanov The role of stem cells in the recovery of hemopoiesis in cytostatic and radial myelosuppressions Бюллетень сибирской медицины миелосупрессии регенерация стволовые кроветворные клетки мезенхимальные стволовые клетки облучение mielosuppressions regeneration stem hemopoietic cells mesenchimal stem cells irradiation |
| title | The role of stem cells in the recovery of hemopoiesis in cytostatic and radial myelosuppressions |
| title_full | The role of stem cells in the recovery of hemopoiesis in cytostatic and radial myelosuppressions |
| title_fullStr | The role of stem cells in the recovery of hemopoiesis in cytostatic and radial myelosuppressions |
| title_full_unstemmed | The role of stem cells in the recovery of hemopoiesis in cytostatic and radial myelosuppressions |
| title_short | The role of stem cells in the recovery of hemopoiesis in cytostatic and radial myelosuppressions |
| title_sort | role of stem cells in the recovery of hemopoiesis in cytostatic and radial myelosuppressions |
| topic | миелосупрессии регенерация стволовые кроветворные клетки мезенхимальные стволовые клетки облучение mielosuppressions regeneration stem hemopoietic cells mesenchimal stem cells irradiation |
| url | https://bulletin.ssmu.ru/jour/article/view/3063 |
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