An engineered M2 macrophage-derived exosomes-loaded electrospun biomimetic periosteum promotes cell recruitment, immunoregulation, and angiogenesis in bone regeneration

An engineered M2 macrophage-derived exosomes-loaded electrospun biomimetic periosteum promotes cell recruitment, immunoregulation, and angiogenesis in bone regeneration

The periosteum, a fibrous tissue membrane covering bone surfaces, is critical to osteogenesis and angiogenesis in bone reconstruction. Artificial periostea have been widely developed for bone defect repair, but most of these are lacking of periosteal bioactivity. Herein, a biomimetic periosteum (ter...

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Bibliographic Details
Main Authors: Zhuohao Wen, Shuyi Li, Yi Liu, Xueyan Liu, Huiguo Qiu, Yuejuan Che, Liming Bian, Miao Zhou
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-08-01
Series:Bioactive Materials
Subjects:
Biomimetic periosteum
Engineered exosome
Osteogenic induction
Immune regulation
Bone regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25001379
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