NK Cells and Type 1 Diabetes
Type 1 diabetes (T1D) is characterized by an immuno-mediated progressive destruction of the pancreatic β cells. Due to the ability of NK cells to kill target cells as well as to interact with antigen-presenting and T cells, it has been suggested that they could be involved in one or multiple steps o...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1080/17402520600877182 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850156920729501696 |
|---|---|
| author | Melanie Rodacki Adolpho Milech José Egídio Paulo de Oliveira |
| author_facet | Melanie Rodacki Adolpho Milech José Egídio Paulo de Oliveira |
| author_sort | Melanie Rodacki |
| collection | DOAJ |
| description | Type 1 diabetes (T1D) is characterized by an immuno-mediated progressive destruction of the pancreatic β cells. Due to the ability of NK cells to kill target cells as well as to interact with antigen-presenting and T cells, it has been suggested that they could be involved in one or multiple steps of the immune-mediated attack that leads to T1D. Abnormalities in the frequency and activity of NK cells have been described both in animal models and patients with T1D. Some of these alterations are linked to its onset while others seem to be a consequence of the disease. Here, we discuss the main characteristics of NK cells and review the studies that investigated the role of NK cells in T1D, both in mouse models and humans. |
| format | Article |
| id | doaj-art-32a90f38719448c69e6a10d86d2d3e0c |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-32a90f38719448c69e6a10d86d2d3e0c2025-08-20T02:24:19ZengWileyClinical and Developmental Immunology1740-25221740-25302006-01-01132-410110710.1080/17402520600877182NK Cells and Type 1 DiabetesMelanie Rodacki0Adolpho Milech1José Egídio Paulo de Oliveira2Diabetes and Nutrology section, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, BrazilDiabetes and Nutrology section, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, BrazilDiabetes and Nutrology section, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, BrazilType 1 diabetes (T1D) is characterized by an immuno-mediated progressive destruction of the pancreatic β cells. Due to the ability of NK cells to kill target cells as well as to interact with antigen-presenting and T cells, it has been suggested that they could be involved in one or multiple steps of the immune-mediated attack that leads to T1D. Abnormalities in the frequency and activity of NK cells have been described both in animal models and patients with T1D. Some of these alterations are linked to its onset while others seem to be a consequence of the disease. Here, we discuss the main characteristics of NK cells and review the studies that investigated the role of NK cells in T1D, both in mouse models and humans.http://dx.doi.org/10.1080/17402520600877182 |
| spellingShingle | Melanie Rodacki Adolpho Milech José Egídio Paulo de Oliveira NK Cells and Type 1 Diabetes Clinical and Developmental Immunology |
| title | NK Cells and Type 1 Diabetes |
| title_full | NK Cells and Type 1 Diabetes |
| title_fullStr | NK Cells and Type 1 Diabetes |
| title_full_unstemmed | NK Cells and Type 1 Diabetes |
| title_short | NK Cells and Type 1 Diabetes |
| title_sort | nk cells and type 1 diabetes |
| url | http://dx.doi.org/10.1080/17402520600877182 |
| work_keys_str_mv | AT melanierodacki nkcellsandtype1diabetes AT adolphomilech nkcellsandtype1diabetes AT joseegidiopaulodeoliveira nkcellsandtype1diabetes |