Intravascular delivery of an ultraflexible neural electrode array for recordings of cortical spiking activity
Abstract Although intracranial neural electrodes have significantly contributed to both fundamental research and clinical treatment of neurological diseases, their implantation requires invasive surgery to open craniotomies, which can introduce brain damage and disrupt normal brain functions. Recent...
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| Format: | Article |
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Nature Portfolio
2024-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-53720-5 |
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| author | Xingzhao Wang Shun Wu Hantao Yang Yu Bao Zhi Li Changchun Gan Yuanyuan Deng Junyan Cao Xue Li Yun Wang Chi Ren Zhigang Yang Zhengtuo Zhao |
| author_facet | Xingzhao Wang Shun Wu Hantao Yang Yu Bao Zhi Li Changchun Gan Yuanyuan Deng Junyan Cao Xue Li Yun Wang Chi Ren Zhigang Yang Zhengtuo Zhao |
| author_sort | Xingzhao Wang |
| collection | DOAJ |
| description | Abstract Although intracranial neural electrodes have significantly contributed to both fundamental research and clinical treatment of neurological diseases, their implantation requires invasive surgery to open craniotomies, which can introduce brain damage and disrupt normal brain functions. Recent emergence of endovascular neural devices offers minimally invasive approaches for neural recording and stimulation. However, existing endovascular neural devices are unable to resolve single-unit activity in large animal models or human patients, impeding a broader application as neural interfaces in clinical practice. Here, we present the ultraflexible implantable neural electrode as an intravascular device (uFINE-I) for recording brain activity at single-unit resolution. We successfully implanted uFINE-Is into the sheep occipital lobe by penetrating through the confluence of sinuses and recorded both local field potentials (LFPs) and multi-channel single-unit spiking activity under spontaneous and visually evoked conditions. Imaging and histological analysis revealed minimal tissue damage and immune response. The uFINE-I provides a practical solution for achieving high-resolution neural recording with minimal invasiveness and can be readily transferred to clinical settings for future neural interface applications such as brain-machine interfaces (BMIs) and the treatment of neurological diseases. |
| format | Article |
| id | doaj-art-32a8c17ed8254ea3aecaecb272a2f3bd |
| institution | OA Journals |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-32a8c17ed8254ea3aecaecb272a2f3bd2025-08-20T02:18:28ZengNature PortfolioNature Communications2041-17232024-11-0115111510.1038/s41467-024-53720-5Intravascular delivery of an ultraflexible neural electrode array for recordings of cortical spiking activityXingzhao Wang0Shun Wu1Hantao Yang2Yu Bao3Zhi Li4Changchun Gan5Yuanyuan Deng6Junyan Cao7Xue Li8Yun Wang9Chi Ren10Zhigang Yang11Zhengtuo Zhao12Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of SciencesInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of SciencesShanghai Geriatric Medical CenterInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of SciencesFudan UniversityInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of SciencesShanghaiTech UniversityUniversity of Shanghai for Science and TechnologyInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of SciencesZhongshan HospitalInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of SciencesZhongshan HospitalInstitute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of SciencesAbstract Although intracranial neural electrodes have significantly contributed to both fundamental research and clinical treatment of neurological diseases, their implantation requires invasive surgery to open craniotomies, which can introduce brain damage and disrupt normal brain functions. Recent emergence of endovascular neural devices offers minimally invasive approaches for neural recording and stimulation. However, existing endovascular neural devices are unable to resolve single-unit activity in large animal models or human patients, impeding a broader application as neural interfaces in clinical practice. Here, we present the ultraflexible implantable neural electrode as an intravascular device (uFINE-I) for recording brain activity at single-unit resolution. We successfully implanted uFINE-Is into the sheep occipital lobe by penetrating through the confluence of sinuses and recorded both local field potentials (LFPs) and multi-channel single-unit spiking activity under spontaneous and visually evoked conditions. Imaging and histological analysis revealed minimal tissue damage and immune response. The uFINE-I provides a practical solution for achieving high-resolution neural recording with minimal invasiveness and can be readily transferred to clinical settings for future neural interface applications such as brain-machine interfaces (BMIs) and the treatment of neurological diseases.https://doi.org/10.1038/s41467-024-53720-5 |
| spellingShingle | Xingzhao Wang Shun Wu Hantao Yang Yu Bao Zhi Li Changchun Gan Yuanyuan Deng Junyan Cao Xue Li Yun Wang Chi Ren Zhigang Yang Zhengtuo Zhao Intravascular delivery of an ultraflexible neural electrode array for recordings of cortical spiking activity Nature Communications |
| title | Intravascular delivery of an ultraflexible neural electrode array for recordings of cortical spiking activity |
| title_full | Intravascular delivery of an ultraflexible neural electrode array for recordings of cortical spiking activity |
| title_fullStr | Intravascular delivery of an ultraflexible neural electrode array for recordings of cortical spiking activity |
| title_full_unstemmed | Intravascular delivery of an ultraflexible neural electrode array for recordings of cortical spiking activity |
| title_short | Intravascular delivery of an ultraflexible neural electrode array for recordings of cortical spiking activity |
| title_sort | intravascular delivery of an ultraflexible neural electrode array for recordings of cortical spiking activity |
| url | https://doi.org/10.1038/s41467-024-53720-5 |
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