The Effects of Ceftriaxone on Glutamate Transporter Expression and the Gut Microbiome: Implications for a Role of Antibiotic-Induced Dysbiosis in Mediating Drug Seeking and Relapse

The Effects of Ceftriaxone on Glutamate Transporter Expression and the Gut Microbiome: Implications for a Role of Antibiotic-Induced Dysbiosis in Mediating Drug Seeking and Relapse

Ceftriaxone (CTX), a beta-lactam antibiotic, is widely used in drug seeking and relapse studies due to its ability to enhance glutamate transporter (GLT-1) expression in the brain. Since increased synaptic glutamate is believed to drive drug seeking and relapse, CTX’s effect on GLT-1 offers potentia...

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Bibliographic Details
Main Authors: Andrew D. Winters, Dina M. Francescutti, David J. Kracht, Donald M. Kuhn, Mariana Angoa-Perez
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Gut Microbes Reports
Subjects:
Ceftriaxone
glutamate transporter
gut micobiota
relapse
Online Access:https://www.tandfonline.com/doi/10.1080/29933935.2024.2393727
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