Accuracy of Ultrasound-Guided Core Biopsy for Staging Axilla in Clinically Node-Negative Patients with Invasive Breast Cancer Taking Histopathology as Gold Standard
Objective: To assess the accuracy of ultrasound-guided core biopsy in staging axillary lymph nodes in clinically node-negative invasive breast cancer patients using histopathology as the gold standard. Methods: This cross-sectional study was conducted in the Department of Pathology at Mekran Medica...
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Dow University of Health Sciences
2024-12-01
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| Series: | Journal of the Dow University of Health Sciences |
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| Online Access: | https://jduhs.jduhs.duhs.edu.pk/index.php/jduhs/article/view/2177 |
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| author | Santosh Kumar Sidhwani Muhammad Waqas Khan Ahmed Hussain Suhag Shumaila Najeeb Lubna Humayun Sehr Syed |
| author_facet | Santosh Kumar Sidhwani Muhammad Waqas Khan Ahmed Hussain Suhag Shumaila Najeeb Lubna Humayun Sehr Syed |
| author_sort | Santosh Kumar Sidhwani |
| collection | DOAJ |
| description |
Objective: To assess the accuracy of ultrasound-guided core biopsy in staging axillary lymph nodes in clinically
node-negative invasive breast cancer patients using histopathology as the gold standard.
Methods: This cross-sectional study was conducted in the Department of Pathology at Mekran Medical College, Turbat, Pakistan, from April 2023 to September 2023. The study included breast cancer patients who were clinically negative for lymph node involvement. Ultrasound-guided core biopsies were performed on suspicious axillary lymph nodes by experienced radiologists, with histopathological analysis serving as the gold standard. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall accuracy were calculated to assess diagnostic performance. Patient demographics, tumor characteristics, and axillary ultrasound findings were also recorded. Results: A total of 132 invasive breast cancer patients were included, with a mean age of 57.67 ± 13.03 years. The majority of patients were diagnosed with invasive ductal carcinoma, accounting for 113 (85.6%) cases. Hormone receptor positivity was prevalent, with estrogen receptor positivity in 119 (90.2%) and progesterone receptor positivity in 116 (87.9%) cases. The most common immunohistochemistry subtype was Luminal B, present in 66 (50%) patients, followed by Luminal A in 51 (38.6%) patients. Most tumors were of moderate grade 77 (58.4%) and early-stage (pT1) 63 (47.7%). Ultrasound-guided core biopsy exhibited a sensitivity of 87.9% and specificity of 100%,
with positive and negative predictive values of 100% and 89.2% respectively, resulting in a diagnostic accuracy of
93.9%.
Conclusion: Ultrasound-guided core biopsy demonstrates strong diagnostic performance in identifying
metastatic axillary lymph nodes in clinically node-negative invasive breast cancer patients.
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| format | Article |
| id | doaj-art-32a6e814a36e401dae38ee8bcc09365a |
| institution | OA Journals |
| issn | 1995-2198 2410-2180 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Dow University of Health Sciences |
| record_format | Article |
| series | Journal of the Dow University of Health Sciences |
| spelling | doaj-art-32a6e814a36e401dae38ee8bcc09365a2025-08-20T02:36:41ZengDow University of Health SciencesJournal of the Dow University of Health Sciences1995-21982410-21802024-12-01183Accuracy of Ultrasound-Guided Core Biopsy for Staging Axilla in Clinically Node-Negative Patients with Invasive Breast Cancer Taking Histopathology as Gold StandardSantosh Kumar Sidhwani0Muhammad Waqas Khan1Ahmed Hussain Suhag2Shumaila Najeeb3Lubna Humayun4Sehr Syed5Department of Pathology, Mekran Medical College, Turbat, PakistanDepartment of Pathology, Mekran Medical College, Turbat, Pakistan.Department of Physiology, Mekran Medical College, Turbat, Pakistan.Department of Histopathology, Mohiuddin Islamic Medical College, AJK, Pakistan.Department of Pathology, University College of Medicine & Dentistry, Lahore, Pakistan.Department of Microbiology, University College of Medicine and Dentistry, Lahore, Pakistan. Objective: To assess the accuracy of ultrasound-guided core biopsy in staging axillary lymph nodes in clinically node-negative invasive breast cancer patients using histopathology as the gold standard. Methods: This cross-sectional study was conducted in the Department of Pathology at Mekran Medical College, Turbat, Pakistan, from April 2023 to September 2023. The study included breast cancer patients who were clinically negative for lymph node involvement. Ultrasound-guided core biopsies were performed on suspicious axillary lymph nodes by experienced radiologists, with histopathological analysis serving as the gold standard. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and overall accuracy were calculated to assess diagnostic performance. Patient demographics, tumor characteristics, and axillary ultrasound findings were also recorded. Results: A total of 132 invasive breast cancer patients were included, with a mean age of 57.67 ± 13.03 years. The majority of patients were diagnosed with invasive ductal carcinoma, accounting for 113 (85.6%) cases. Hormone receptor positivity was prevalent, with estrogen receptor positivity in 119 (90.2%) and progesterone receptor positivity in 116 (87.9%) cases. The most common immunohistochemistry subtype was Luminal B, present in 66 (50%) patients, followed by Luminal A in 51 (38.6%) patients. Most tumors were of moderate grade 77 (58.4%) and early-stage (pT1) 63 (47.7%). Ultrasound-guided core biopsy exhibited a sensitivity of 87.9% and specificity of 100%, with positive and negative predictive values of 100% and 89.2% respectively, resulting in a diagnostic accuracy of 93.9%. Conclusion: Ultrasound-guided core biopsy demonstrates strong diagnostic performance in identifying metastatic axillary lymph nodes in clinically node-negative invasive breast cancer patients. https://jduhs.jduhs.duhs.edu.pk/index.php/jduhs/article/view/2177AxillaryBiopsyBreast NeoplasmsLymph Nodes |
| spellingShingle | Santosh Kumar Sidhwani Muhammad Waqas Khan Ahmed Hussain Suhag Shumaila Najeeb Lubna Humayun Sehr Syed Accuracy of Ultrasound-Guided Core Biopsy for Staging Axilla in Clinically Node-Negative Patients with Invasive Breast Cancer Taking Histopathology as Gold Standard Journal of the Dow University of Health Sciences Axillary Biopsy Breast Neoplasms Lymph Nodes |
| title | Accuracy of Ultrasound-Guided Core Biopsy for Staging Axilla in Clinically Node-Negative Patients with Invasive Breast Cancer Taking Histopathology as Gold Standard |
| title_full | Accuracy of Ultrasound-Guided Core Biopsy for Staging Axilla in Clinically Node-Negative Patients with Invasive Breast Cancer Taking Histopathology as Gold Standard |
| title_fullStr | Accuracy of Ultrasound-Guided Core Biopsy for Staging Axilla in Clinically Node-Negative Patients with Invasive Breast Cancer Taking Histopathology as Gold Standard |
| title_full_unstemmed | Accuracy of Ultrasound-Guided Core Biopsy for Staging Axilla in Clinically Node-Negative Patients with Invasive Breast Cancer Taking Histopathology as Gold Standard |
| title_short | Accuracy of Ultrasound-Guided Core Biopsy for Staging Axilla in Clinically Node-Negative Patients with Invasive Breast Cancer Taking Histopathology as Gold Standard |
| title_sort | accuracy of ultrasound guided core biopsy for staging axilla in clinically node negative patients with invasive breast cancer taking histopathology as gold standard |
| topic | Axillary Biopsy Breast Neoplasms Lymph Nodes |
| url | https://jduhs.jduhs.duhs.edu.pk/index.php/jduhs/article/view/2177 |
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