Valproic Acid Enhances the Anticancer Effect of L-Ascorbic Acid by Upregulating Sodium-Dependent Vitamin C Transporter 2 in Colorectal Cancer

Valproic Acid Enhances the Anticancer Effect of L-Ascorbic Acid by Upregulating Sodium-Dependent Vitamin C Transporter 2 in Colorectal Cancer

Vitamin C, also known as L-ascorbic acid (AA), functions as a pro-oxidant in cancer at high doses and exerts anticancer effects by generating reactive oxygen species (ROS) and selectively inducing damage to cancer cells. However, AA at low doses promotes cancer cell proliferation. The efficacy of hi...

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Bibliographic Details
Main Authors: Kawalin Kantawong, Hakim Meutia Diva, Phuong T. Ho, Ahlim Lee, Misae Kiba, Mi-Gi Lee, Hee Kang, Taek-Kyun Lee, Sukchan Lee
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Antioxidants
Subjects:
SVCT2
vitamin C
pro-oxidant
valproic acid
colorectal cancer
Online Access:https://www.mdpi.com/2076-3921/14/7/864
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