PD-1/CTLA-4 Blockade Inhibits Epstein-Barr Virus-Induced Lymphoma Growth in a Cord Blood Humanized-Mouse Model.

PD-1/CTLA-4 Blockade Inhibits Epstein-Barr Virus-Induced Lymphoma Growth in a Cord Blood Humanized-Mouse Model.

Epstein-Barr virus (EBV) infection causes B cell lymphomas in humanized mouse models and contributes to a variety of different types of human lymphomas. T cells directed against viral antigens play a critical role in controlling EBV infection, and EBV-positive lymphomas are particularly common in im...

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Bibliographic Details
Main Authors: Shi-Dong Ma, Xuequn Xu, Richard Jones, Henri-Jacques Delecluse, Nicholas A Zumwalde, Akshat Sharma, Jenny E Gumperz, Shannon C Kenney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-05-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005642&type=printable
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