Probiotic Microorganisms in Inflammatory Bowel Diseases: Live Biotherapeutics as Food
(1) Background: Inflammatory bowel diseases (IBDs) are characterized by chronic and complex inflammatory processes of the digestive tract that evolve with frequent relapses and manifest at any age; they predominantly affect young individuals. Diet plays a direct role in maintaining the gut mucosal i...
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MDPI AG
2024-12-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/13/24/4097 |
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| author | Emanuelle Natalee Santos Karina Teixeira Magalhães-Guedes Fernando Elias de Melo Borges Danton Diego Ferreira Daniele Ferreira da Silva Pietro Carlos Gonçalves Conceição Ana Katerine de Carvalho Lima Lucas Guimarães Cardoso Marcelo Andrés Umsza-Guez Cíntia Lacerda Ramos |
| author_facet | Emanuelle Natalee Santos Karina Teixeira Magalhães-Guedes Fernando Elias de Melo Borges Danton Diego Ferreira Daniele Ferreira da Silva Pietro Carlos Gonçalves Conceição Ana Katerine de Carvalho Lima Lucas Guimarães Cardoso Marcelo Andrés Umsza-Guez Cíntia Lacerda Ramos |
| author_sort | Emanuelle Natalee Santos |
| collection | DOAJ |
| description | (1) Background: Inflammatory bowel diseases (IBDs) are characterized by chronic and complex inflammatory processes of the digestive tract that evolve with frequent relapses and manifest at any age; they predominantly affect young individuals. Diet plays a direct role in maintaining the gut mucosal integrity and immune function. Regarding the diet, the administration of probiotics stands out. The use of probiotics for IBD treatment has shown promising effects on consumers’ quality of life. (2) Methods: This study aimed to conduct a literature review on the effects of probiotic and smart probiotic ingestion on IBD and analyze the available literature based on the searched keywords using boxplot diagrams to search for scientific data in the online literature published up to October 2024. (3) Results: Google Scholar (containing ~6 × 10<sup>6</sup> articles) and Science Direct (containing ~5 × 10<sup>6</sup> articles) were the databases with the highest number of articles for the keywords used in the study. When analyzing the content of the articles, although probiotic microorganisms are currently not part of the standard treatment protocol for IBD, these live biotherapeutics have proven to be an effective treatment option, considering the adverse effects of conventional therapies. Furthermore, the development of genetically engineered probiotics or smart probiotics is a promising treatment for IBD. (4) Conclusions: Probiotics and smart probiotics could represent the future of nutritional medicine in IBD care, allowing patients to be treated in a more natural, safe, effective, and nutritious way. However, although many studies have demonstrated the potential of this biotherapy, clinical trials standardizing dosage and strains are still necessary. |
| format | Article |
| id | doaj-art-32a0a5a2ed2343c8844e8a7e565eb638 |
| institution | DOAJ |
| issn | 2304-8158 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-32a0a5a2ed2343c8844e8a7e565eb6382025-08-20T02:55:52ZengMDPI AGFoods2304-81582024-12-011324409710.3390/foods13244097Probiotic Microorganisms in Inflammatory Bowel Diseases: Live Biotherapeutics as FoodEmanuelle Natalee Santos0Karina Teixeira Magalhães-Guedes1Fernando Elias de Melo Borges2Danton Diego Ferreira3Daniele Ferreira da Silva4Pietro Carlos Gonçalves Conceição5Ana Katerine de Carvalho Lima6Lucas Guimarães Cardoso7Marcelo Andrés Umsza-Guez8Cíntia Lacerda Ramos9Post-Graduate Program in Food Science, Federal University of Vale of Jequitinhonha and Mucuri (UFVJM), Street MGT 367—Km 583, No. 5000, Alto da Jacuba, Diamantina 39100-000, MG, BrazilPost-Graduate Program in Chemistry Engineering, Polytechnic School, Federal University of Bahia (UFBA) and Salvador University (UNIFACS), Street Professor Aristídes Novis, 02, Federação, Salvador 40210-630, BA, BrazilPost-Graduate Program in Systems Engineering and Automation, Department of Automatic, Federal University of Lavras (UFLA), University Campus, Lavras 37000-200, MG, BrazilPost-Graduate Program in Systems Engineering and Automation, Department of Automatic, Federal University of Lavras (UFLA), University Campus, Lavras 37000-200, MG, BrazilPost-Graduate Program in Food Science, Federal University of Vale of Jequitinhonha and Mucuri (UFVJM), Street MGT 367—Km 583, No. 5000, Alto da Jacuba, Diamantina 39100-000, MG, BrazilPost-Graduate Program in Chemistry Engineering, Polytechnic School, Federal University of Bahia (UFBA) and Salvador University (UNIFACS), Street Professor Aristídes Novis, 02, Federação, Salvador 40210-630, BA, BrazilPost-Graduate Program in Chemistry Engineering, Polytechnic School, Federal University of Bahia (UFBA) and Salvador University (UNIFACS), Street Professor Aristídes Novis, 02, Federação, Salvador 40210-630, BA, BrazilPost-Graduate Program in Chemistry Engineering, Polytechnic School, Federal University of Bahia (UFBA) and Salvador University (UNIFACS), Street Professor Aristídes Novis, 02, Federação, Salvador 40210-630, BA, BrazilPost-Graduate Program in Food Science, Federal University of Bahia (UFBA), Barão of Geremoabo Street, s/n, Ondina, Salvador 40171-970, BA, BrazilPost-Graduate Program in Food Science, Federal University of Vale of Jequitinhonha and Mucuri (UFVJM), Street MGT 367—Km 583, No. 5000, Alto da Jacuba, Diamantina 39100-000, MG, Brazil(1) Background: Inflammatory bowel diseases (IBDs) are characterized by chronic and complex inflammatory processes of the digestive tract that evolve with frequent relapses and manifest at any age; they predominantly affect young individuals. Diet plays a direct role in maintaining the gut mucosal integrity and immune function. Regarding the diet, the administration of probiotics stands out. The use of probiotics for IBD treatment has shown promising effects on consumers’ quality of life. (2) Methods: This study aimed to conduct a literature review on the effects of probiotic and smart probiotic ingestion on IBD and analyze the available literature based on the searched keywords using boxplot diagrams to search for scientific data in the online literature published up to October 2024. (3) Results: Google Scholar (containing ~6 × 10<sup>6</sup> articles) and Science Direct (containing ~5 × 10<sup>6</sup> articles) were the databases with the highest number of articles for the keywords used in the study. When analyzing the content of the articles, although probiotic microorganisms are currently not part of the standard treatment protocol for IBD, these live biotherapeutics have proven to be an effective treatment option, considering the adverse effects of conventional therapies. Furthermore, the development of genetically engineered probiotics or smart probiotics is a promising treatment for IBD. (4) Conclusions: Probiotics and smart probiotics could represent the future of nutritional medicine in IBD care, allowing patients to be treated in a more natural, safe, effective, and nutritious way. However, although many studies have demonstrated the potential of this biotherapy, clinical trials standardizing dosage and strains are still necessary.https://www.mdpi.com/2304-8158/13/24/4097Crohn’s diseaseulcerative colitissmart probioticboxplot |
| spellingShingle | Emanuelle Natalee Santos Karina Teixeira Magalhães-Guedes Fernando Elias de Melo Borges Danton Diego Ferreira Daniele Ferreira da Silva Pietro Carlos Gonçalves Conceição Ana Katerine de Carvalho Lima Lucas Guimarães Cardoso Marcelo Andrés Umsza-Guez Cíntia Lacerda Ramos Probiotic Microorganisms in Inflammatory Bowel Diseases: Live Biotherapeutics as Food Foods Crohn’s disease ulcerative colitis smart probiotic boxplot |
| title | Probiotic Microorganisms in Inflammatory Bowel Diseases: Live Biotherapeutics as Food |
| title_full | Probiotic Microorganisms in Inflammatory Bowel Diseases: Live Biotherapeutics as Food |
| title_fullStr | Probiotic Microorganisms in Inflammatory Bowel Diseases: Live Biotherapeutics as Food |
| title_full_unstemmed | Probiotic Microorganisms in Inflammatory Bowel Diseases: Live Biotherapeutics as Food |
| title_short | Probiotic Microorganisms in Inflammatory Bowel Diseases: Live Biotherapeutics as Food |
| title_sort | probiotic microorganisms in inflammatory bowel diseases live biotherapeutics as food |
| topic | Crohn’s disease ulcerative colitis smart probiotic boxplot |
| url | https://www.mdpi.com/2304-8158/13/24/4097 |
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