Predictive value of biliverdin reductase‐A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes
ABSTRACT Aims/Introduction To investigate the predictive value of the biliverdin reductase‐A (BVR‐A) and the homeostasis model assessment for insulin resistance (HOMA‐IR) on mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus, and to establish a nomogram model. Materials and Me...
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| Format: | Article |
| Language: | English |
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Wiley
2025-05-01
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| Series: | Journal of Diabetes Investigation |
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| Online Access: | https://doi.org/10.1111/jdi.70020 |
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| author | Li Shen Xiaole Wei Nan Wang Haorui Lv Jing Huang Xiaoyan Zhou Aifang Cheng Changjiang Ying |
| author_facet | Li Shen Xiaole Wei Nan Wang Haorui Lv Jing Huang Xiaoyan Zhou Aifang Cheng Changjiang Ying |
| author_sort | Li Shen |
| collection | DOAJ |
| description | ABSTRACT Aims/Introduction To investigate the predictive value of the biliverdin reductase‐A (BVR‐A) and the homeostasis model assessment for insulin resistance (HOMA‐IR) on mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus, and to establish a nomogram model. Materials and Methods This study included 140 patients with type 2 diabetes mellitus. Based on Montreal Cognitive Assessment (MoCA) scores, participants were categorized into the normal cognitive function (T2DM‐NCF) group (65 cases) and the mild cognitive impairment (T2DM‐MCI) group (75 cases). Multivariate logistic regression analysis was performed to identify the factors associated with MCI in patients with type 2 diabetes mellitus. A nomogram prediction model was developed using R software for the selected factors, and its predictability and accuracy were verified. Results Compared with the T2DM‐NCF group, subjects with MCI were older, had a longer duration of diabetes, higher HOMA‐IR, lower BVR‐A, lower cognitive scores, and lower education levels (all P < 0.05). Multivariate logistic regression analysis showed that duration of diabetes (OR = 1.407, 95% CI: 1.163–1.701), HOMA‐IR (OR = 1.741, 95% CI: 1.197–2.53), and BVR‐A (OR = 0.528, 95% CI: 0.392–0.712) were significantly associated with the development of MCI in patients with type 2 diabetes mellitus. The C‐index of the nomogram was 0.863 (95% CI: 0.752–0.937). Conclusions Our findings suggest that BVR‐A and HOMA‐IR are significantly associated with the development of MCI in patients with type 2 diabetes mellitus. The nomogram incorporating BVR‐A and HOMA‐IR aids in predicting the risk of developing MCI in these patients. |
| format | Article |
| id | doaj-art-32a044eb1d6b490daa68c254fd57716a |
| institution | OA Journals |
| issn | 2040-1116 2040-1124 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj-art-32a044eb1d6b490daa68c254fd57716a2025-08-20T02:27:19ZengWileyJournal of Diabetes Investigation2040-11162040-11242025-05-0116593694410.1111/jdi.70020Predictive value of biliverdin reductase‐A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetesLi Shen0Xiaole Wei1Nan Wang2Haorui Lv3Jing Huang4Xiaoyan Zhou5Aifang Cheng6Changjiang Ying7The First Clinical Medical College Xuzhou Medical University Xuzhou Jiangsu ChinaThe First Clinical Medical College Xuzhou Medical University Xuzhou Jiangsu ChinaThe First Clinical Medical College Xuzhou Medical University Xuzhou Jiangsu ChinaThe First Clinical Medical College Xuzhou Medical University Xuzhou Jiangsu ChinaThe First Clinical Medical College Xuzhou Medical University Xuzhou Jiangsu ChinaDepartment of Genetics Xuzhou Medical University Xuzhou Jiangsu ChinaDepartment of Biomedical Sciences, Faculty of Health Sciences University of Macau Macao SAR ChinaDepartment of Endocrinology Affiliated Hospital of Xuzhou Medical University Xuzhou ChinaABSTRACT Aims/Introduction To investigate the predictive value of the biliverdin reductase‐A (BVR‐A) and the homeostasis model assessment for insulin resistance (HOMA‐IR) on mild cognitive impairment (MCI) in patients with type 2 diabetes mellitus, and to establish a nomogram model. Materials and Methods This study included 140 patients with type 2 diabetes mellitus. Based on Montreal Cognitive Assessment (MoCA) scores, participants were categorized into the normal cognitive function (T2DM‐NCF) group (65 cases) and the mild cognitive impairment (T2DM‐MCI) group (75 cases). Multivariate logistic regression analysis was performed to identify the factors associated with MCI in patients with type 2 diabetes mellitus. A nomogram prediction model was developed using R software for the selected factors, and its predictability and accuracy were verified. Results Compared with the T2DM‐NCF group, subjects with MCI were older, had a longer duration of diabetes, higher HOMA‐IR, lower BVR‐A, lower cognitive scores, and lower education levels (all P < 0.05). Multivariate logistic regression analysis showed that duration of diabetes (OR = 1.407, 95% CI: 1.163–1.701), HOMA‐IR (OR = 1.741, 95% CI: 1.197–2.53), and BVR‐A (OR = 0.528, 95% CI: 0.392–0.712) were significantly associated with the development of MCI in patients with type 2 diabetes mellitus. The C‐index of the nomogram was 0.863 (95% CI: 0.752–0.937). Conclusions Our findings suggest that BVR‐A and HOMA‐IR are significantly associated with the development of MCI in patients with type 2 diabetes mellitus. The nomogram incorporating BVR‐A and HOMA‐IR aids in predicting the risk of developing MCI in these patients.https://doi.org/10.1111/jdi.70020Biliverdin reductase‐ACognitive impairment in diabetesInsulin resistance |
| spellingShingle | Li Shen Xiaole Wei Nan Wang Haorui Lv Jing Huang Xiaoyan Zhou Aifang Cheng Changjiang Ying Predictive value of biliverdin reductase‐A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes Journal of Diabetes Investigation Biliverdin reductase‐A Cognitive impairment in diabetes Insulin resistance |
| title | Predictive value of biliverdin reductase‐A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes |
| title_full | Predictive value of biliverdin reductase‐A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes |
| title_fullStr | Predictive value of biliverdin reductase‐A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes |
| title_full_unstemmed | Predictive value of biliverdin reductase‐A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes |
| title_short | Predictive value of biliverdin reductase‐A and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes |
| title_sort | predictive value of biliverdin reductase a and homeostasis model assessment of insulin resistance on mild cognitive impairment in patients with type 2 diabetes |
| topic | Biliverdin reductase‐A Cognitive impairment in diabetes Insulin resistance |
| url | https://doi.org/10.1111/jdi.70020 |
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