Antibiotics combined with vaginal probiotics in the embryo transfer cycle of infertile patients with chronic endometritis
IntroductionChronic endometritis (CE) is a prolonged, mild inflammation of the endometrial lining. This study investigated the impact of the impact of antibiotic treatment combined with vaginal Lactobacillus on pregnancy outcomes in infertile patients with CE during frozen embryo transfer (FET) cycl...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1494931/full |
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| author | Ping Hu Ping Hu Mengyue Chen Mengyue Chen Lu Zhu Lu Zhu Bing Song Chao Wang Xiaojin He Xiaojin He Guanjian Li Guanjian Li Yunxia Cao Yunxia Cao |
| author_facet | Ping Hu Ping Hu Mengyue Chen Mengyue Chen Lu Zhu Lu Zhu Bing Song Chao Wang Xiaojin He Xiaojin He Guanjian Li Guanjian Li Yunxia Cao Yunxia Cao |
| author_sort | Ping Hu |
| collection | DOAJ |
| description | IntroductionChronic endometritis (CE) is a prolonged, mild inflammation of the endometrial lining. This study investigated the impact of the impact of antibiotic treatment combined with vaginal Lactobacillus on pregnancy outcomes in infertile patients with CE during frozen embryo transfer (FET) cycles.MethodsA retrospective analysis was performed on the clinical data of 7,385 patients who underwent FET. After applying the inclusion and exclusion criteria, 254 patients diagnosed with CE were eligible for inclusion. Of these, 119 patients received antibiotics alone, whereas 135 were treated with a combination of doxycycline and vaginal Lactobacillus. All patients underwent embryo transfer within 6 months following treatment. The general characteristics and pregnancy outcomes of the first FET cycle post-treatment were compared between the two groups.ResultsThere were no statistically significant differences between the two groups in terms of general characteristics, clinical pregnancy rate, early miscarriage rate, and ectopic pregnancy rate. Patients who received a combination of doxycycline and Lactobacillus showed a higher biochemical pregnancy rate compared to those who received doxycycline alone, though this difference was not statistically significant (70.37% vs. 64.71%, P=0.313). Furthermore, the incidence rate of premature rupture of membranes was lower in the doxycycline-Lactobacillus group than in the doxycycline group (50.00% vs 33.33%, P=0.037).ConclusionsAlthough this study observed the potential benefits of the antibiotic and vaginal probiotic treatment regimen in increasing the biochemical pregnancy rate and reducing the incidence of premature rupture of membranes, the current findings are insufficient to recommend the combined use of antibiotics and vaginal Lactobacillus as an intervention to improve reproductive outcomes in infertile patients with CE. |
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| issn | 2235-2988 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-329f7370951a4ece853f8ac6c8d2119d2025-08-20T01:54:15ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882024-11-011410.3389/fcimb.2024.14949311494931Antibiotics combined with vaginal probiotics in the embryo transfer cycle of infertile patients with chronic endometritisPing Hu0Ping Hu1Mengyue Chen2Mengyue Chen3Lu Zhu4Lu Zhu5Bing Song6Chao Wang7Xiaojin He8Xiaojin He9Guanjian Li10Guanjian Li11Yunxia Cao12Yunxia Cao13Reproductive Medicine Center, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaNational Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, ChinaReproductive Medicine Center, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaKey Laboratory of Population Health Across Life Cycle, Ministry of Education of the People’s Republic of China, Hefei, Anhui, ChinaReproductive Medicine Center, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaReproductive Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNational Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, ChinaKey Laboratory of Population Health Across Life Cycle, Ministry of Education of the People’s Republic of China, Hefei, Anhui, ChinaReproductive Medicine Center, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaReproductive Medicine Center, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaReproductive Medicine Center, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaNational Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, ChinaReproductive Medicine Center, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaNational Health Commission Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Hefei, Anhui, ChinaIntroductionChronic endometritis (CE) is a prolonged, mild inflammation of the endometrial lining. This study investigated the impact of the impact of antibiotic treatment combined with vaginal Lactobacillus on pregnancy outcomes in infertile patients with CE during frozen embryo transfer (FET) cycles.MethodsA retrospective analysis was performed on the clinical data of 7,385 patients who underwent FET. After applying the inclusion and exclusion criteria, 254 patients diagnosed with CE were eligible for inclusion. Of these, 119 patients received antibiotics alone, whereas 135 were treated with a combination of doxycycline and vaginal Lactobacillus. All patients underwent embryo transfer within 6 months following treatment. The general characteristics and pregnancy outcomes of the first FET cycle post-treatment were compared between the two groups.ResultsThere were no statistically significant differences between the two groups in terms of general characteristics, clinical pregnancy rate, early miscarriage rate, and ectopic pregnancy rate. Patients who received a combination of doxycycline and Lactobacillus showed a higher biochemical pregnancy rate compared to those who received doxycycline alone, though this difference was not statistically significant (70.37% vs. 64.71%, P=0.313). Furthermore, the incidence rate of premature rupture of membranes was lower in the doxycycline-Lactobacillus group than in the doxycycline group (50.00% vs 33.33%, P=0.037).ConclusionsAlthough this study observed the potential benefits of the antibiotic and vaginal probiotic treatment regimen in increasing the biochemical pregnancy rate and reducing the incidence of premature rupture of membranes, the current findings are insufficient to recommend the combined use of antibiotics and vaginal Lactobacillus as an intervention to improve reproductive outcomes in infertile patients with CE.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1494931/fullchronic endometritisvaginal probioticsantibioticsLactobacillusIVF-ET |
| spellingShingle | Ping Hu Ping Hu Mengyue Chen Mengyue Chen Lu Zhu Lu Zhu Bing Song Chao Wang Xiaojin He Xiaojin He Guanjian Li Guanjian Li Yunxia Cao Yunxia Cao Antibiotics combined with vaginal probiotics in the embryo transfer cycle of infertile patients with chronic endometritis Frontiers in Cellular and Infection Microbiology chronic endometritis vaginal probiotics antibiotics Lactobacillus IVF-ET |
| title | Antibiotics combined with vaginal probiotics in the embryo transfer cycle of infertile patients with chronic endometritis |
| title_full | Antibiotics combined with vaginal probiotics in the embryo transfer cycle of infertile patients with chronic endometritis |
| title_fullStr | Antibiotics combined with vaginal probiotics in the embryo transfer cycle of infertile patients with chronic endometritis |
| title_full_unstemmed | Antibiotics combined with vaginal probiotics in the embryo transfer cycle of infertile patients with chronic endometritis |
| title_short | Antibiotics combined with vaginal probiotics in the embryo transfer cycle of infertile patients with chronic endometritis |
| title_sort | antibiotics combined with vaginal probiotics in the embryo transfer cycle of infertile patients with chronic endometritis |
| topic | chronic endometritis vaginal probiotics antibiotics Lactobacillus IVF-ET |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1494931/full |
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