Activation of telomerase via madecassic acid enhances the developmental competence of the SCNT-derived bovine embryos

Activation of telomerase via madecassic acid enhances the developmental competence of the SCNT-derived bovine embryos

Somatic cell nuclear transfer (SCNT) is important in assisted reproductive technologies. However, its reprogramming efficiency remains low. A considerable drawback of SCNT-cloned embryos is the reduction in telomerase activity, which is crucial for DNA stability and genetic and epigenetic reprogramm...

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Bibliographic Details
Main Authors: Zaheer Haider, Safeer Ullah, Tahir Muhammad, Chalani Dilshani Perera, Muhammad Tayyab Khan, Asif Jan, Seung-Eun Lee, Seo-Hyun Lee, Sung Woo Kim, Muhammad Idrees, Il-Keun Kong
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
SCNT
art
telomerase
in vitro embryo production (IVP)
madecassic acid (MA)
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1628953/full
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