The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer
Urogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium , the infectious agent of urogenital schistosomiasis, relea...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-03-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317692247 |
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| _version_ | 1849428733561143296 |
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| author | Nuno Vale Maria J Gouveia Gabriel Rinaldi Júlio Santos Lúcio Lara Santos Paul J Brindley José M Correia da Costa |
| author_facet | Nuno Vale Maria J Gouveia Gabriel Rinaldi Júlio Santos Lúcio Lara Santos Paul J Brindley José M Correia da Costa |
| author_sort | Nuno Vale |
| collection | DOAJ |
| description | Urogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium , the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aiming for enhanced understanding of the pathogenesis of the urogenital schistosomiasis-induced bladder cancer, here we review, interpret, and discuss findings of estradiol-like metabolites detected in both the parasite and in the human urine during urogenital schistosomiasis. Moreover, we predict pathways and enzymes that are involved in the production of these metabolites emphasizing their potential effects on the dysregulation of the tumor suppressor gene p53 expression during urogenital schistosomiasis. Enhanced understanding of these potential carcinogens may not only shed light on urogenital schistosomiasis-induced neoplasia of the bladder, but would also facilitate development of interventions and biomarkers for this and other infection-associated cancers at large. |
| format | Article |
| id | doaj-art-3295eabc299845f68bb2f14967607b9c |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-3295eabc299845f68bb2f14967607b9c2025-08-20T03:28:37ZengSAGE PublishingTumor Biology1423-03802017-03-013910.1177/1010428317692247The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancerNuno Vale0Maria J Gouveia1Gabriel Rinaldi2Júlio Santos3Lúcio Lara Santos4Paul J Brindley5José M Correia da Costa6UCIBIO/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Porto, PortugalCenter for the Study of Animal Science, ICETA, University of Porto, Porto, PortugalThe Wellcome Trust Sanger Institute, Cambridge, UKExperimental Pathology and Therapeutics Group, Research Center of Instituto Português de Oncologia, Porto, PortugalExperimental Pathology and Therapeutics Group, Research Center of Instituto Português de Oncologia, Porto, PortugalDepartment of Microbiology, Immunology, & Tropical Medicine and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, DC, USADepartment of Infectious Diseases, R&D Unit, National Health Institute Doutor Ricardo Jorge (INSA), Porto, PortugalUrogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium , the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aiming for enhanced understanding of the pathogenesis of the urogenital schistosomiasis-induced bladder cancer, here we review, interpret, and discuss findings of estradiol-like metabolites detected in both the parasite and in the human urine during urogenital schistosomiasis. Moreover, we predict pathways and enzymes that are involved in the production of these metabolites emphasizing their potential effects on the dysregulation of the tumor suppressor gene p53 expression during urogenital schistosomiasis. Enhanced understanding of these potential carcinogens may not only shed light on urogenital schistosomiasis-induced neoplasia of the bladder, but would also facilitate development of interventions and biomarkers for this and other infection-associated cancers at large.https://doi.org/10.1177/1010428317692247 |
| spellingShingle | Nuno Vale Maria J Gouveia Gabriel Rinaldi Júlio Santos Lúcio Lara Santos Paul J Brindley José M Correia da Costa The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer Tumor Biology |
| title | The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer |
| title_full | The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer |
| title_fullStr | The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer |
| title_full_unstemmed | The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer |
| title_short | The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer |
| title_sort | role of estradiol metabolism in urogenital schistosomiasis induced bladder cancer |
| url | https://doi.org/10.1177/1010428317692247 |
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