Efficacy of sarilumab and dexamethasone co-administration for lowering multiple blood biomarkers in the treatment of cytokine release syndrome in hospitalized covid-19 patients
The current study was planned to explore the potential synergistic role of the co-administration of sarilumab and dexamethasone in reducing blood biomarkers associated with cytokine release syndrome in hospitalised patients of coronavirus disease-2019. The sample comprised 22 patients hospitalised...
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| Language: | English |
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Pakistan Medical Association
2024-06-01
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| Series: | Journal of the Pakistan Medical Association |
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| Online Access: | https://jpma.org.pk/index.php/public_html/article/view/10480 |
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| author | Ishtiaq Ahmad Hamidullah |
| author_facet | Ishtiaq Ahmad Hamidullah |
| author_sort | Ishtiaq Ahmad |
| collection | DOAJ |
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The current study was planned to explore the potential synergistic role of the co-administration of sarilumab and dexamethasone in reducing blood biomarkers associated with cytokine release syndrome in hospitalised patients of coronavirus disease-2019. The sample comprised 22 patients hospitalised with severe and critical severity levels and who were treated with sarilumab and dexamethasone. Positive responses were seen in blood biomarkers, including decreased interleukin-6 alpha levels and improved oxygen saturation. Tumour necrosis factor, D-dimer, C-reactive protein, ferritin and lymphocyte count also showed positive responses in patients who survived than those who died. Lactate dehydrogenase levels fluctuated with improvement among the survivors, but had limited effectiveness in those who died. The findings suggested promising avenues for future treatment strategies in patients with severe coronavirus disease-2019 and cytokine release syndrome.
Key Words: Sarilumab, Dexamethasone, Biomarkers, Cytokine release syndrome, COVID-19.
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| format | Article |
| id | doaj-art-32909c2d25a149309e72ee8bfaad4864 |
| institution | Kabale University |
| issn | 0030-9982 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj-art-32909c2d25a149309e72ee8bfaad48642025-08-20T03:40:00ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822024-06-0174710.47391/JPMA.10480Efficacy of sarilumab and dexamethasone co-administration for lowering multiple blood biomarkers in the treatment of cytokine release syndrome in hospitalized covid-19 patientsIshtiaq Ahmad0Hamidullah1Department of Medicine, Mardan Medical complex, Bacha Khan Medical College, Mardan, PakistanDepartment of Medicine, Mardan Medical complex, Bacha Khan Medical College, Mardan, Pakistan The current study was planned to explore the potential synergistic role of the co-administration of sarilumab and dexamethasone in reducing blood biomarkers associated with cytokine release syndrome in hospitalised patients of coronavirus disease-2019. The sample comprised 22 patients hospitalised with severe and critical severity levels and who were treated with sarilumab and dexamethasone. Positive responses were seen in blood biomarkers, including decreased interleukin-6 alpha levels and improved oxygen saturation. Tumour necrosis factor, D-dimer, C-reactive protein, ferritin and lymphocyte count also showed positive responses in patients who survived than those who died. Lactate dehydrogenase levels fluctuated with improvement among the survivors, but had limited effectiveness in those who died. The findings suggested promising avenues for future treatment strategies in patients with severe coronavirus disease-2019 and cytokine release syndrome. Key Words: Sarilumab, Dexamethasone, Biomarkers, Cytokine release syndrome, COVID-19. https://jpma.org.pk/index.php/public_html/article/view/10480SarilumabDexamethasoneBiomarkersCytokine Release SyndromeCovid-19 |
| spellingShingle | Ishtiaq Ahmad Hamidullah Efficacy of sarilumab and dexamethasone co-administration for lowering multiple blood biomarkers in the treatment of cytokine release syndrome in hospitalized covid-19 patients Journal of the Pakistan Medical Association Sarilumab Dexamethasone Biomarkers Cytokine Release Syndrome Covid-19 |
| title | Efficacy of sarilumab and dexamethasone co-administration for lowering multiple blood biomarkers in the treatment of cytokine release syndrome in hospitalized covid-19 patients |
| title_full | Efficacy of sarilumab and dexamethasone co-administration for lowering multiple blood biomarkers in the treatment of cytokine release syndrome in hospitalized covid-19 patients |
| title_fullStr | Efficacy of sarilumab and dexamethasone co-administration for lowering multiple blood biomarkers in the treatment of cytokine release syndrome in hospitalized covid-19 patients |
| title_full_unstemmed | Efficacy of sarilumab and dexamethasone co-administration for lowering multiple blood biomarkers in the treatment of cytokine release syndrome in hospitalized covid-19 patients |
| title_short | Efficacy of sarilumab and dexamethasone co-administration for lowering multiple blood biomarkers in the treatment of cytokine release syndrome in hospitalized covid-19 patients |
| title_sort | efficacy of sarilumab and dexamethasone co administration for lowering multiple blood biomarkers in the treatment of cytokine release syndrome in hospitalized covid 19 patients |
| topic | Sarilumab Dexamethasone Biomarkers Cytokine Release Syndrome Covid-19 |
| url | https://jpma.org.pk/index.php/public_html/article/view/10480 |
| work_keys_str_mv | AT ishtiaqahmad efficacyofsarilumabanddexamethasonecoadministrationforloweringmultiplebloodbiomarkersinthetreatmentofcytokinereleasesyndromeinhospitalizedcovid19patients AT hamidullah efficacyofsarilumabanddexamethasonecoadministrationforloweringmultiplebloodbiomarkersinthetreatmentofcytokinereleasesyndromeinhospitalizedcovid19patients |