Construction of a prostate adenocarcinoma molecular classification: integrating spatial transcriptomics with retrospective cohort validation

Construction of a prostate adenocarcinoma molecular classification: integrating spatial transcriptomics with retrospective cohort validation

Abstract Background Prostate adenocarcinoma (PRAD) is a biologically heterogeneous disease threatening the health of elderly males worldwide, and some PRAD subtypes with certain molecular landscape are always associated with poor prognosis. A more precise molecular classification system for PRAD is...

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Main Authors: Bingnan Lu, Yifan Liu, Guo Ji, Yuntao Yao, Zhao Yang, Bolin Zhu, Lei Wang, Keqin Dong, Yuanan Li, Jiaying Shi, Junzhe He, Runzhi Huang, Wang Zhou, Xinming Cui, Xiuwu Pan, Xingang Cui
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Prostate adenocarcinoma
Molecular classification system
Cell differentiation
Spatial transcriptome
Immunohistochemical staining
Retrospective clinical cohort validation
Online Access:https://doi.org/10.1186/s12967-025-06661-6
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