Changes in serum sodium concentration during hemodialysis is a predictor of mortality and cardio-cerebrovascular event
Background Previous study consistently showed that lower serum sodium (SNa) was associated with a greater risk of mortality in hemodialysis (HD) patients. However, few studies have focused on the change in SNa (ΔSNa = post-HD SNa – pre-HD SNa) during an HD session.Methods In a retrospective cohort o...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2338483 |
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| author | Qixing Liu Ke Zheng Haiyun Wang Dan Song Xuemei Li |
| author_facet | Qixing Liu Ke Zheng Haiyun Wang Dan Song Xuemei Li |
| author_sort | Qixing Liu |
| collection | DOAJ |
| description | Background Previous study consistently showed that lower serum sodium (SNa) was associated with a greater risk of mortality in hemodialysis (HD) patients. However, few studies have focused on the change in SNa (ΔSNa = post-HD SNa – pre-HD SNa) during an HD session.Methods In a retrospective cohort of maintenance HD adults, all-cause mortality and cardio-cerebrovascular event (CCVE) were followed up for a medium of 82 months. Baseline pre-HD SNa and ΔSNa were collected; time-averaged pre-HD SNa and ΔSNa were computed as the mean values within 1-year, 2-year and 3-year intervals after enrollment. Cox proportional hazards models were used to evaluate the relationships of pre-HD and ΔSNa with outcomes.Results Time-averaged pre-HD SNa were associated with all-cause mortality (2-year pre-HD SNa: HR [95% CI] 0.86 [0.74–0.99], p = 0.042) and CCVE (3-year pre-HD SNa: HR [95% CI] 0.83 [0.72–0.96], p = 0.012) with full adjustment. Time-averaged ΔSNa also demonstrated an association with all-cause mortality (3-year ΔSNa: HR [95% CI] 1.26 [1.03–1.55], p = 0.026) as well as with CCVE (3-year ΔSNa: HR [95% CI] 1.51 [1.21–1.88], p = <0.001) when fully adjusted. Baseline pre-HD SNa and ΔSNa didn’t exhibit association with both outcomes.Conclusions Lower time-averaged pre-HD SNa and higher time-averaged ΔSNa were associated with a greater risk of all-cause mortality and CCVE in HD patients. |
| format | Article |
| id | doaj-art-326b621c66bf40b98e07ecb941f0b93a |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-326b621c66bf40b98e07ecb941f0b93a2025-01-23T04:17:49ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146110.1080/0886022X.2024.2338483Changes in serum sodium concentration during hemodialysis is a predictor of mortality and cardio-cerebrovascular eventQixing Liu0Ke Zheng1Haiyun Wang2Dan Song3Xuemei Li4Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBackground Previous study consistently showed that lower serum sodium (SNa) was associated with a greater risk of mortality in hemodialysis (HD) patients. However, few studies have focused on the change in SNa (ΔSNa = post-HD SNa – pre-HD SNa) during an HD session.Methods In a retrospective cohort of maintenance HD adults, all-cause mortality and cardio-cerebrovascular event (CCVE) were followed up for a medium of 82 months. Baseline pre-HD SNa and ΔSNa were collected; time-averaged pre-HD SNa and ΔSNa were computed as the mean values within 1-year, 2-year and 3-year intervals after enrollment. Cox proportional hazards models were used to evaluate the relationships of pre-HD and ΔSNa with outcomes.Results Time-averaged pre-HD SNa were associated with all-cause mortality (2-year pre-HD SNa: HR [95% CI] 0.86 [0.74–0.99], p = 0.042) and CCVE (3-year pre-HD SNa: HR [95% CI] 0.83 [0.72–0.96], p = 0.012) with full adjustment. Time-averaged ΔSNa also demonstrated an association with all-cause mortality (3-year ΔSNa: HR [95% CI] 1.26 [1.03–1.55], p = 0.026) as well as with CCVE (3-year ΔSNa: HR [95% CI] 1.51 [1.21–1.88], p = <0.001) when fully adjusted. Baseline pre-HD SNa and ΔSNa didn’t exhibit association with both outcomes.Conclusions Lower time-averaged pre-HD SNa and higher time-averaged ΔSNa were associated with a greater risk of all-cause mortality and CCVE in HD patients.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2338483CardiovascularESRDhemodialysismortalityserum sodium |
| spellingShingle | Qixing Liu Ke Zheng Haiyun Wang Dan Song Xuemei Li Changes in serum sodium concentration during hemodialysis is a predictor of mortality and cardio-cerebrovascular event Renal Failure Cardiovascular ESRD hemodialysis mortality serum sodium |
| title | Changes in serum sodium concentration during hemodialysis is a predictor of mortality and cardio-cerebrovascular event |
| title_full | Changes in serum sodium concentration during hemodialysis is a predictor of mortality and cardio-cerebrovascular event |
| title_fullStr | Changes in serum sodium concentration during hemodialysis is a predictor of mortality and cardio-cerebrovascular event |
| title_full_unstemmed | Changes in serum sodium concentration during hemodialysis is a predictor of mortality and cardio-cerebrovascular event |
| title_short | Changes in serum sodium concentration during hemodialysis is a predictor of mortality and cardio-cerebrovascular event |
| title_sort | changes in serum sodium concentration during hemodialysis is a predictor of mortality and cardio cerebrovascular event |
| topic | Cardiovascular ESRD hemodialysis mortality serum sodium |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2338483 |
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