Constructing Polymetallic Nodes in Metal–Organic Frameworks Enhance Antibacterial of Drug‐Resistant Bacteria
Abstract The misuse of antibiotics results in the emergence of a large number of drug‐resistant bacteria, which leads to huge financial and social burdens. Exploring artificial nanozymes is regarded as a promising candidates for the substitution of antibiotics, but still remain a huge challenge. Her...
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| Format: | Article |
| Language: | English |
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Wiley
2025-07-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202501327 |
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| author | Qinqin Li Shihan Zhang Yachao Xu Yaru Guo Youxing Liu |
| author_facet | Qinqin Li Shihan Zhang Yachao Xu Yaru Guo Youxing Liu |
| author_sort | Qinqin Li |
| collection | DOAJ |
| description | Abstract The misuse of antibiotics results in the emergence of a large number of drug‐resistant bacteria, which leads to huge financial and social burdens. Exploring artificial nanozymes is regarded as a promising candidates for the substitution of antibiotics, but still remain a huge challenge. Herein, a new strategy is reported for constructing polymetallic indium coordination node Metal‐organic frameworks (MOFs) (polyIn‐BTB) for enhancing the production of reactive oxygen species (ROS), which significantly promote antibacterial activity. Theoretical research reveals that, compared to monometallic indium coordination node MOFs (monoIn‐BTB), polyIn‐BTB exhibits a stronger electron‐donating ability, which can facilitate the efficient production of ROS. Thus, polyIn‐BTB shows outstanding antibacterial properties of 87.0% and 92.0% for Methicillin‐Resistant Staphylococcus aureus (MRS. aureus) and Escherichia coli (E. coli) respectively, which is significantly higher than that of monoIn‐BTB (42% for MRS. Aureus and 50% for E. coli). The in vivo experiments demonstrate that polyIn‐BTB accelerates wound healing by killing bacteria and inhibiting the inflammatory response they cause, with a wound healing rate of 98.0% in 8 days. Overall, this work reports a new strategy for constructing polyIn‐BTB for enhancing the antibacterial performance, which opens the door to fundamental research on designing the nanozyme with high performance. |
| format | Article |
| id | doaj-art-32644f983b6a48deb4d13fdfb224cb41 |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-32644f983b6a48deb4d13fdfb224cb412025-08-20T03:30:48ZengWileyAdvanced Science2198-38442025-07-011225n/an/a10.1002/advs.202501327Constructing Polymetallic Nodes in Metal–Organic Frameworks Enhance Antibacterial of Drug‐Resistant BacteriaQinqin Li0Shihan Zhang1Yachao Xu2Yaru Guo3Youxing Liu4Beijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing University of Chemical Technology Beijing 100029 ChinaDepartment of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 ChinaSchool of Materials Science and Engineering Peking University Beijing 100871 ChinaDepartment of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 ChinaBeijing Key Laboratory of Electrochemical Process and Technology for Materials Beijing University of Chemical Technology Beijing 100029 ChinaAbstract The misuse of antibiotics results in the emergence of a large number of drug‐resistant bacteria, which leads to huge financial and social burdens. Exploring artificial nanozymes is regarded as a promising candidates for the substitution of antibiotics, but still remain a huge challenge. Herein, a new strategy is reported for constructing polymetallic indium coordination node Metal‐organic frameworks (MOFs) (polyIn‐BTB) for enhancing the production of reactive oxygen species (ROS), which significantly promote antibacterial activity. Theoretical research reveals that, compared to monometallic indium coordination node MOFs (monoIn‐BTB), polyIn‐BTB exhibits a stronger electron‐donating ability, which can facilitate the efficient production of ROS. Thus, polyIn‐BTB shows outstanding antibacterial properties of 87.0% and 92.0% for Methicillin‐Resistant Staphylococcus aureus (MRS. aureus) and Escherichia coli (E. coli) respectively, which is significantly higher than that of monoIn‐BTB (42% for MRS. Aureus and 50% for E. coli). The in vivo experiments demonstrate that polyIn‐BTB accelerates wound healing by killing bacteria and inhibiting the inflammatory response they cause, with a wound healing rate of 98.0% in 8 days. Overall, this work reports a new strategy for constructing polyIn‐BTB for enhancing the antibacterial performance, which opens the door to fundamental research on designing the nanozyme with high performance.https://doi.org/10.1002/advs.202501327antibacterialantibacterial therapymetal–organic framework materialspolymetallic coordination nodereactive oxygen species |
| spellingShingle | Qinqin Li Shihan Zhang Yachao Xu Yaru Guo Youxing Liu Constructing Polymetallic Nodes in Metal–Organic Frameworks Enhance Antibacterial of Drug‐Resistant Bacteria Advanced Science antibacterial antibacterial therapy metal–organic framework materials polymetallic coordination node reactive oxygen species |
| title | Constructing Polymetallic Nodes in Metal–Organic Frameworks Enhance Antibacterial of Drug‐Resistant Bacteria |
| title_full | Constructing Polymetallic Nodes in Metal–Organic Frameworks Enhance Antibacterial of Drug‐Resistant Bacteria |
| title_fullStr | Constructing Polymetallic Nodes in Metal–Organic Frameworks Enhance Antibacterial of Drug‐Resistant Bacteria |
| title_full_unstemmed | Constructing Polymetallic Nodes in Metal–Organic Frameworks Enhance Antibacterial of Drug‐Resistant Bacteria |
| title_short | Constructing Polymetallic Nodes in Metal–Organic Frameworks Enhance Antibacterial of Drug‐Resistant Bacteria |
| title_sort | constructing polymetallic nodes in metal organic frameworks enhance antibacterial of drug resistant bacteria |
| topic | antibacterial antibacterial therapy metal–organic framework materials polymetallic coordination node reactive oxygen species |
| url | https://doi.org/10.1002/advs.202501327 |
| work_keys_str_mv | AT qinqinli constructingpolymetallicnodesinmetalorganicframeworksenhanceantibacterialofdrugresistantbacteria AT shihanzhang constructingpolymetallicnodesinmetalorganicframeworksenhanceantibacterialofdrugresistantbacteria AT yachaoxu constructingpolymetallicnodesinmetalorganicframeworksenhanceantibacterialofdrugresistantbacteria AT yaruguo constructingpolymetallicnodesinmetalorganicframeworksenhanceantibacterialofdrugresistantbacteria AT youxingliu constructingpolymetallicnodesinmetalorganicframeworksenhanceantibacterialofdrugresistantbacteria |