c-Jun promotes neuroblastoma cell differentiation by inhibiting APC formation via CDC16 and reduces neuroblastoma malignancy

c-Jun promotes neuroblastoma cell differentiation by inhibiting APC formation via CDC16 and reduces neuroblastoma malignancy

Abstract Neuroblastoma is a pediatric embryonal malignancy characterized by impaired neuronal differentiation. Differentiation status in neuroblastoma strongly affects the clinical outcome, thus, enforcement of differentiation becomes a treatment strategy for this disease. However, the molecular mec...

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Bibliographic Details
Main Authors: Yunyun Wang, Jingjing Huang, Zhenhua Song, Shuo Zhang, Haojie Guo, Qi Leng, Na Fang, Shaoping Ji, Jian Yang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Biology Direct
Subjects:
c-Jun
CDC16
Anaphase-promoting complex
Cell differentiation
Neuroblastoma
Online Access:https://doi.org/10.1186/s13062-025-00630-1
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