Risk factors for complications after reduction mammaplasty: a systematic review and meta-analysis
Abstract Background Reduction mammaplasty (RM) is a commonly performed plastic surgery procedure, but various postoperative complications have been noted. This study aims to identify and quantify the association between risk factors and the occurrence of postoperative complications following RM. Met...
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BMC
2025-06-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02723-z |
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| author | Ran Ran Hao Wang Xing He Junjie Li Miao Yu Exian Mou Caiyang Liu |
| author_facet | Ran Ran Hao Wang Xing He Junjie Li Miao Yu Exian Mou Caiyang Liu |
| author_sort | Ran Ran |
| collection | DOAJ |
| description | Abstract Background Reduction mammaplasty (RM) is a commonly performed plastic surgery procedure, but various postoperative complications have been noted. This study aims to identify and quantify the association between risk factors and the occurrence of postoperative complications following RM. Methods We systematically reviewed PubMed, Medline, Cochrane Library and Web of Science for relevant publications, extracting suspected risk factors and associated postoperative complications. Meta-analyses were then conducted to evaluate their associations. Results We included 61 articles encompassing 71,149 patients. Seven suspected risk factors and eighteen complications were identified. Five risk factors were significantly associated with any complications after RM: body mass index (BMI) ≥ 30 kg/m2 (OR 1.59, 95% CI 1.45–1.74, p = 0.000, I2 = 35.2%); smoking (OR 1.80, 95% CI 1.29–2.50, p = 0.000, I2 = 87.5%); diabetes (OR 1.41, 95% CI 1.11–1.79, p = 0.005, I2 = 11.2%); previous radiation therapy (OR 3.24, 95% CI 1.94–5.40, p = 0.000, I2 = 12.6%); and surgical techniques including inferior pedicle (IP) vs. superomedial pedicle (SMP) (OR 1.59, 95% CI 1.27–1.99, p = 0.000, I2 = 27.5%); IP vs. medial pedicle (MP) (OR 2.34, 95% CI 1.48–3.72, p = 0.000, I2 = 47.0%); and superior pedicle vs. SMP (OR 0.59, 95% CI 0.37–0.95, p = 0.028, I2 = 0.0%). Furthermore, BMI ≥ 30 kg/m2 was linked to higher risks of delayed healing, fat necrosis, wound infection, and dehiscence. Previous radiation therapy increased the risks of fat necrosis, wound infection, and seroma. Smoking was associated with higher risks of wound infection and dehiscence. Compared to MP, IP had a higher risk of wound dehiscence; compared to SMP, IP had a higher risk of wound infection but a lower risk of seroma (all P < 0.05). Conclusions These findings highlight the importance of comprehensive preoperative risk assessment and individualized surgical planning to minimize postoperative complications and improve patient outcomes. |
| format | Article |
| id | doaj-art-325e55598cc34f8d9e98cee8129cadf9 |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-325e55598cc34f8d9e98cee8129cadf92025-08-20T03:25:18ZengBMCEuropean Journal of Medical Research2047-783X2025-06-0130111810.1186/s40001-025-02723-zRisk factors for complications after reduction mammaplasty: a systematic review and meta-analysisRan Ran0Hao Wang1Xing He2Junjie Li3Miao Yu4Exian Mou5Caiyang Liu6Breast Surgery Center of Sichuan Cancer HospitalBreast Surgery Center of Sichuan Cancer HospitalDepartment of Blood Transfusion, Jinniu District People’s HospitalBreast Surgery Center of Sichuan Cancer HospitalBreast Surgery Center of Sichuan Cancer HospitalBreast Surgery Center of Sichuan Cancer HospitalDepartment of Cardiothoracic Surgery, The First People’s Hospital of NeijiangAbstract Background Reduction mammaplasty (RM) is a commonly performed plastic surgery procedure, but various postoperative complications have been noted. This study aims to identify and quantify the association between risk factors and the occurrence of postoperative complications following RM. Methods We systematically reviewed PubMed, Medline, Cochrane Library and Web of Science for relevant publications, extracting suspected risk factors and associated postoperative complications. Meta-analyses were then conducted to evaluate their associations. Results We included 61 articles encompassing 71,149 patients. Seven suspected risk factors and eighteen complications were identified. Five risk factors were significantly associated with any complications after RM: body mass index (BMI) ≥ 30 kg/m2 (OR 1.59, 95% CI 1.45–1.74, p = 0.000, I2 = 35.2%); smoking (OR 1.80, 95% CI 1.29–2.50, p = 0.000, I2 = 87.5%); diabetes (OR 1.41, 95% CI 1.11–1.79, p = 0.005, I2 = 11.2%); previous radiation therapy (OR 3.24, 95% CI 1.94–5.40, p = 0.000, I2 = 12.6%); and surgical techniques including inferior pedicle (IP) vs. superomedial pedicle (SMP) (OR 1.59, 95% CI 1.27–1.99, p = 0.000, I2 = 27.5%); IP vs. medial pedicle (MP) (OR 2.34, 95% CI 1.48–3.72, p = 0.000, I2 = 47.0%); and superior pedicle vs. SMP (OR 0.59, 95% CI 0.37–0.95, p = 0.028, I2 = 0.0%). Furthermore, BMI ≥ 30 kg/m2 was linked to higher risks of delayed healing, fat necrosis, wound infection, and dehiscence. Previous radiation therapy increased the risks of fat necrosis, wound infection, and seroma. Smoking was associated with higher risks of wound infection and dehiscence. Compared to MP, IP had a higher risk of wound dehiscence; compared to SMP, IP had a higher risk of wound infection but a lower risk of seroma (all P < 0.05). Conclusions These findings highlight the importance of comprehensive preoperative risk assessment and individualized surgical planning to minimize postoperative complications and improve patient outcomes.https://doi.org/10.1186/s40001-025-02723-zReduction mammaplastyPostoperative complicationsRisk factorsMeta-analysis |
| spellingShingle | Ran Ran Hao Wang Xing He Junjie Li Miao Yu Exian Mou Caiyang Liu Risk factors for complications after reduction mammaplasty: a systematic review and meta-analysis European Journal of Medical Research Reduction mammaplasty Postoperative complications Risk factors Meta-analysis |
| title | Risk factors for complications after reduction mammaplasty: a systematic review and meta-analysis |
| title_full | Risk factors for complications after reduction mammaplasty: a systematic review and meta-analysis |
| title_fullStr | Risk factors for complications after reduction mammaplasty: a systematic review and meta-analysis |
| title_full_unstemmed | Risk factors for complications after reduction mammaplasty: a systematic review and meta-analysis |
| title_short | Risk factors for complications after reduction mammaplasty: a systematic review and meta-analysis |
| title_sort | risk factors for complications after reduction mammaplasty a systematic review and meta analysis |
| topic | Reduction mammaplasty Postoperative complications Risk factors Meta-analysis |
| url | https://doi.org/10.1186/s40001-025-02723-z |
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