The regenerating gene (Reg) family genes in inflammatory bowel disease (IBD)
Regenerating gene (Reg) was first isolated in 1988 and proposed to be specifically expressed in rat regenerating pancreatic islets. Since then, many genes homologous to Reg have been discovered in other species, including humans, mice, hamsters, rabbits, sheep, dogs, cats, pigs, giant pandas, chicke...
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Open Exploration Publishing Inc.
2025-02-01
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| Series: | Exploration of Medicine |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A1001278/1001278.pdf |
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| author | Shin Takasawa Tomoko Uchiyama Maiko Takeda |
| author_facet | Shin Takasawa Tomoko Uchiyama Maiko Takeda |
| author_sort | Shin Takasawa |
| collection | DOAJ |
| description | Regenerating gene (Reg) was first isolated in 1988 and proposed to be specifically expressed in rat regenerating pancreatic islets. Since then, many genes homologous to Reg have been discovered in other species, including humans, mice, hamsters, rabbits, sheep, dogs, cats, pigs, giant pandas, chickens, and frogs. Moreover, Reg and its related genes (Reg family genes) have been classified as types I, II, III, and IV. They are closely associated with cell and tissue regeneration, cell proliferation, and anti-apoptosis in various tissues and cells including pancreatic β cells. In particular, focusing on the digestive organs and tissues, there have been reports that they play important roles not only in stomach, colon, liver, and pancreatic duct cancer, but also in intestinal epithelial cells, especially inflammatory bowel diseases (IBD), such as Crohn’s disease (CD) and ulcerative colitis (UC). This review describes and discusses the expression of Reg family genes in intestinal epithelial cells of those affected by IBD and the molecular mechanisms underlying this expression. |
| format | Article |
| id | doaj-art-325a59265dc843a794597ee1f262c214 |
| institution | Kabale University |
| issn | 2692-3106 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Open Exploration Publishing Inc. |
| record_format | Article |
| series | Exploration of Medicine |
| spelling | doaj-art-325a59265dc843a794597ee1f262c2142025-02-08T03:05:28ZengOpen Exploration Publishing Inc.Exploration of Medicine2692-31062025-02-016100127810.37349/emed.2025.1001278The regenerating gene (Reg) family genes in inflammatory bowel disease (IBD)Shin Takasawa0https://orcid.org/0000-0002-4066-0199Tomoko Uchiyama1Maiko Takeda2Department of Biochemistry, Nara Medical University, Kashihara 634-8521, JapanDepartment of Diagnostic Pathology, Nara Medical University, Kashihara 634-8522, JapanDepartment of Diagnostic Pathology, Nara Medical University, Kashihara 634-8522, JapanRegenerating gene (Reg) was first isolated in 1988 and proposed to be specifically expressed in rat regenerating pancreatic islets. Since then, many genes homologous to Reg have been discovered in other species, including humans, mice, hamsters, rabbits, sheep, dogs, cats, pigs, giant pandas, chickens, and frogs. Moreover, Reg and its related genes (Reg family genes) have been classified as types I, II, III, and IV. They are closely associated with cell and tissue regeneration, cell proliferation, and anti-apoptosis in various tissues and cells including pancreatic β cells. In particular, focusing on the digestive organs and tissues, there have been reports that they play important roles not only in stomach, colon, liver, and pancreatic duct cancer, but also in intestinal epithelial cells, especially inflammatory bowel diseases (IBD), such as Crohn’s disease (CD) and ulcerative colitis (UC). This review describes and discusses the expression of Reg family genes in intestinal epithelial cells of those affected by IBD and the molecular mechanisms underlying this expression.https://www.explorationpub.com/uploads/Article/A1001278/1001278.pdfreg family genesinflammatory bowel diseases (ibd)crohn’s diseaseulcerative colitispancreatic β cellsil-6il-22lipopolysaccharide (lps) |
| spellingShingle | Shin Takasawa Tomoko Uchiyama Maiko Takeda The regenerating gene (Reg) family genes in inflammatory bowel disease (IBD) Exploration of Medicine reg family genes inflammatory bowel diseases (ibd) crohn’s disease ulcerative colitis pancreatic β cells il-6 il-22 lipopolysaccharide (lps) |
| title | The regenerating gene (Reg) family genes in inflammatory bowel disease (IBD) |
| title_full | The regenerating gene (Reg) family genes in inflammatory bowel disease (IBD) |
| title_fullStr | The regenerating gene (Reg) family genes in inflammatory bowel disease (IBD) |
| title_full_unstemmed | The regenerating gene (Reg) family genes in inflammatory bowel disease (IBD) |
| title_short | The regenerating gene (Reg) family genes in inflammatory bowel disease (IBD) |
| title_sort | regenerating gene reg family genes in inflammatory bowel disease ibd |
| topic | reg family genes inflammatory bowel diseases (ibd) crohn’s disease ulcerative colitis pancreatic β cells il-6 il-22 lipopolysaccharide (lps) |
| url | https://www.explorationpub.com/uploads/Article/A1001278/1001278.pdf |
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