Twice Daily Prazosin and Valproic Acid in the Treatment of Flashbacks in PTSD
Posttraumatic stress disorder (PTSD) is a debilitating stress disorder occurring in the context of a traumatic event and is characterized by intrusive and avoidance symptoms, negative alterations in cognition and mood, and arousal and reactivity changes. Despite its representation throughout literat...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2022/1223292 |
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| author | Kristy A. Fisher Heidi Kiziah Clara L. Villalba Alvarez |
| author_facet | Kristy A. Fisher Heidi Kiziah Clara L. Villalba Alvarez |
| author_sort | Kristy A. Fisher |
| collection | DOAJ |
| description | Posttraumatic stress disorder (PTSD) is a debilitating stress disorder occurring in the context of a traumatic event and is characterized by intrusive and avoidance symptoms, negative alterations in cognition and mood, and arousal and reactivity changes. Despite its representation throughout literature, the pathophysiology of PTSD remains incompletely understood, thus contributing to broad, variable, and at times, experimental treatment options. The authors present the first documented case of the rapid and successful management of PTSD using valproic acid and twice daily dosing of prazosin aimed at targeting symptoms of hyperarousal and both daily and nightly intrusive symptoms of flashbacks and nightmares, respectively. The authors also discuss postulations of the underlying mechanisms of action responsible for such symptom alleviation. Further investigation is needed to expand upon our knowledge of the use of such agents in the treatment of PTSD to improve upon existing clinical guidelines, especially in the acute setting, thus providing better overall prognosis. |
| format | Article |
| id | doaj-art-325a1cd2d9cf4a679650946f0f5db451 |
| institution | Kabale University |
| issn | 2090-6838 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-325a1cd2d9cf4a679650946f0f5db4512025-02-03T06:11:50ZengWileyCase Reports in Psychiatry2090-68382022-01-01202210.1155/2022/1223292Twice Daily Prazosin and Valproic Acid in the Treatment of Flashbacks in PTSDKristy A. Fisher0Heidi Kiziah1Clara L. Villalba Alvarez2HCA Aventura Hospital and Medical CenterNova Southeastern UniversityHCA Aventura Hospital and Medical CenterPosttraumatic stress disorder (PTSD) is a debilitating stress disorder occurring in the context of a traumatic event and is characterized by intrusive and avoidance symptoms, negative alterations in cognition and mood, and arousal and reactivity changes. Despite its representation throughout literature, the pathophysiology of PTSD remains incompletely understood, thus contributing to broad, variable, and at times, experimental treatment options. The authors present the first documented case of the rapid and successful management of PTSD using valproic acid and twice daily dosing of prazosin aimed at targeting symptoms of hyperarousal and both daily and nightly intrusive symptoms of flashbacks and nightmares, respectively. The authors also discuss postulations of the underlying mechanisms of action responsible for such symptom alleviation. Further investigation is needed to expand upon our knowledge of the use of such agents in the treatment of PTSD to improve upon existing clinical guidelines, especially in the acute setting, thus providing better overall prognosis.http://dx.doi.org/10.1155/2022/1223292 |
| spellingShingle | Kristy A. Fisher Heidi Kiziah Clara L. Villalba Alvarez Twice Daily Prazosin and Valproic Acid in the Treatment of Flashbacks in PTSD Case Reports in Psychiatry |
| title | Twice Daily Prazosin and Valproic Acid in the Treatment of Flashbacks in PTSD |
| title_full | Twice Daily Prazosin and Valproic Acid in the Treatment of Flashbacks in PTSD |
| title_fullStr | Twice Daily Prazosin and Valproic Acid in the Treatment of Flashbacks in PTSD |
| title_full_unstemmed | Twice Daily Prazosin and Valproic Acid in the Treatment of Flashbacks in PTSD |
| title_short | Twice Daily Prazosin and Valproic Acid in the Treatment of Flashbacks in PTSD |
| title_sort | twice daily prazosin and valproic acid in the treatment of flashbacks in ptsd |
| url | http://dx.doi.org/10.1155/2022/1223292 |
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