Dance Training Improves Cytokine Secretion and Viability of Neutrophils in Diabetic Patients
Background. Evidence suggests that exercise improves neutrophil function. The decreased functional longevity of neutrophils and their increased clearance from infectious sites contribute to the increased susceptibility to infection and severity of infection observed in patients with diabetes. Object...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/2924818 |
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| author | Leandro Borges Maria E. P. Passos Maysa B. B. Silva Vinicius C. Santos César M. Momesso Tania C. Pithon-Curi Renata Gorjão Stuart R. Gray Kauê C. A. Lima Paulo B. de Freitas Elaine Hatanaka |
| author_facet | Leandro Borges Maria E. P. Passos Maysa B. B. Silva Vinicius C. Santos César M. Momesso Tania C. Pithon-Curi Renata Gorjão Stuart R. Gray Kauê C. A. Lima Paulo B. de Freitas Elaine Hatanaka |
| author_sort | Leandro Borges |
| collection | DOAJ |
| description | Background. Evidence suggests that exercise improves neutrophil function. The decreased functional longevity of neutrophils and their increased clearance from infectious sites contribute to the increased susceptibility to infection and severity of infection observed in patients with diabetes. Objective. Herein, we investigated the effects of a dance program on neutrophil number, function, and death in type 2 diabetes mellitus (T2DM) patients and healthy volunteers. Methods. Ten patients with T2DM and twelve healthy individuals participated in a moderate-intensity dance training program for 4 months. The plasma levels of leptin, free fatty acids (FFAs), tumour necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-1β (IL-1β), and interleukin-1 receptor antagonist (IL-1ra); neutrophil counts; extent of DNA fragmentation; cell membrane integrity; and production of TNF-α, interleukin-8 (IL-8), interleukin-6 (IL-6), and IL-1β in neutrophils were measured before and after training. Results. Training reduced plasma levels of TNF-α (1.9-fold in controls and 2.2-fold in patients with T2DM) and CRP (1.4-fold in controls and 3.4-fold in patients with T2DM). IL-1ra levels were higher in the control group (2.2-fold) after training. After training, neutrophil DNA fragmentation was decreased in patients with T2DM (90%), while the number of neutrophils increased (70% in controls and 1.1-fold in patients with T2DM). Conclusion. Dance training is a nonpharmacological strategy to reduce inflammation and improve neutrophil clearance in patients with T2DM. |
| format | Article |
| id | doaj-art-3257e5f2f3bb4cf4a80fff27b829c698 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-3257e5f2f3bb4cf4a80fff27b829c6982025-08-20T03:55:03ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/29248182924818Dance Training Improves Cytokine Secretion and Viability of Neutrophils in Diabetic PatientsLeandro Borges0Maria E. P. Passos1Maysa B. B. Silva2Vinicius C. Santos3César M. Momesso4Tania C. Pithon-Curi5Renata Gorjão6Stuart R. Gray7Kauê C. A. Lima8Paulo B. de Freitas9Elaine Hatanaka10Institute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, BrazilInstitute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, BrazilInstitute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, BrazilSão Paulo University (USP), São Paulo 05508-900, BrazilInstitute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, BrazilInstitute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, BrazilInstitute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, BrazilInstitute of Cardiovascular & Medical Sciences, University of Glasgow, Glasgow G12 8TA, UKInstitute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, BrazilInstitute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, BrazilInstitute of Physical Activity and Sports Sciences, Cruzeiro do Sul University, São Paulo 01506-000, BrazilBackground. Evidence suggests that exercise improves neutrophil function. The decreased functional longevity of neutrophils and their increased clearance from infectious sites contribute to the increased susceptibility to infection and severity of infection observed in patients with diabetes. Objective. Herein, we investigated the effects of a dance program on neutrophil number, function, and death in type 2 diabetes mellitus (T2DM) patients and healthy volunteers. Methods. Ten patients with T2DM and twelve healthy individuals participated in a moderate-intensity dance training program for 4 months. The plasma levels of leptin, free fatty acids (FFAs), tumour necrosis factor-α (TNF-α), C-reactive protein (CRP), interleukin-1β (IL-1β), and interleukin-1 receptor antagonist (IL-1ra); neutrophil counts; extent of DNA fragmentation; cell membrane integrity; and production of TNF-α, interleukin-8 (IL-8), interleukin-6 (IL-6), and IL-1β in neutrophils were measured before and after training. Results. Training reduced plasma levels of TNF-α (1.9-fold in controls and 2.2-fold in patients with T2DM) and CRP (1.4-fold in controls and 3.4-fold in patients with T2DM). IL-1ra levels were higher in the control group (2.2-fold) after training. After training, neutrophil DNA fragmentation was decreased in patients with T2DM (90%), while the number of neutrophils increased (70% in controls and 1.1-fold in patients with T2DM). Conclusion. Dance training is a nonpharmacological strategy to reduce inflammation and improve neutrophil clearance in patients with T2DM.http://dx.doi.org/10.1155/2019/2924818 |
| spellingShingle | Leandro Borges Maria E. P. Passos Maysa B. B. Silva Vinicius C. Santos César M. Momesso Tania C. Pithon-Curi Renata Gorjão Stuart R. Gray Kauê C. A. Lima Paulo B. de Freitas Elaine Hatanaka Dance Training Improves Cytokine Secretion and Viability of Neutrophils in Diabetic Patients Mediators of Inflammation |
| title | Dance Training Improves Cytokine Secretion and Viability of Neutrophils in Diabetic Patients |
| title_full | Dance Training Improves Cytokine Secretion and Viability of Neutrophils in Diabetic Patients |
| title_fullStr | Dance Training Improves Cytokine Secretion and Viability of Neutrophils in Diabetic Patients |
| title_full_unstemmed | Dance Training Improves Cytokine Secretion and Viability of Neutrophils in Diabetic Patients |
| title_short | Dance Training Improves Cytokine Secretion and Viability of Neutrophils in Diabetic Patients |
| title_sort | dance training improves cytokine secretion and viability of neutrophils in diabetic patients |
| url | http://dx.doi.org/10.1155/2019/2924818 |
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