Mesenchymal Stem Cells in Preclinical Infertility Cytotherapy: A Retrospective Review
Infertility is a global reproductive disorder which is caused by a variety of complex diseases. Infertility affects the individual, family, and community through physical, psychological, social and economic consequences. The results from recent preclinical studies regarding stem cell-based therapies...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/8882368 |
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| _version_ | 1849306494364811264 |
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| author | Zhuo Chang Hui Zhu Xueming Zhou Yang Zhang Bei Jiang Shuoxi Li Lu Chen Xue Pan Xiao-ling Feng |
| author_facet | Zhuo Chang Hui Zhu Xueming Zhou Yang Zhang Bei Jiang Shuoxi Li Lu Chen Xue Pan Xiao-ling Feng |
| author_sort | Zhuo Chang |
| collection | DOAJ |
| description | Infertility is a global reproductive disorder which is caused by a variety of complex diseases. Infertility affects the individual, family, and community through physical, psychological, social and economic consequences. The results from recent preclinical studies regarding stem cell-based therapies are promising. Stem cell-based therapies cast a new hope for infertility treatment as a replacement or regeneration strategy. The main features and application prospects of mesenchymal stem cells in the future of infertility should be understood by clinicians. Mesenchymal stem cells (MSCs) are multipotent stem cells with abundant source, active proliferation, and multidirectional differentiation potential. MSCs play a role through cell homing, secretion of active factors, and participation in immune regulation. Another advantage is that, compared with embryonic stem cells, there are fewer ethical factors involved in the application of MSCs. However, a number of questions remain to be answered prior to safe and effective clinical application. In this review, we summarized the recent status of MSCs in the application of the diseases related to or may cause to infertility and suggest a possible direction for future cytotherapy to infertility. |
| format | Article |
| id | doaj-art-324f8e08cc664ebb9a3f736a91afee09 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-324f8e08cc664ebb9a3f736a91afee092025-08-20T03:55:03ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/88823688882368Mesenchymal Stem Cells in Preclinical Infertility Cytotherapy: A Retrospective ReviewZhuo Chang0Hui Zhu1Xueming Zhou2Yang Zhang3Bei Jiang4Shuoxi Li5Lu Chen6Xue Pan7Xiao-ling Feng8Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaHeilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaHeilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaFirst Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaHeilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaJiamusi College of Heilongjiang University of Traditional Chinese Medicine, Jiamusi, Heilongjiang, ChinaFirst Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaBeijing University of Traditional Chinese Medicine, Beijing, ChinaFirst Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, ChinaInfertility is a global reproductive disorder which is caused by a variety of complex diseases. Infertility affects the individual, family, and community through physical, psychological, social and economic consequences. The results from recent preclinical studies regarding stem cell-based therapies are promising. Stem cell-based therapies cast a new hope for infertility treatment as a replacement or regeneration strategy. The main features and application prospects of mesenchymal stem cells in the future of infertility should be understood by clinicians. Mesenchymal stem cells (MSCs) are multipotent stem cells with abundant source, active proliferation, and multidirectional differentiation potential. MSCs play a role through cell homing, secretion of active factors, and participation in immune regulation. Another advantage is that, compared with embryonic stem cells, there are fewer ethical factors involved in the application of MSCs. However, a number of questions remain to be answered prior to safe and effective clinical application. In this review, we summarized the recent status of MSCs in the application of the diseases related to or may cause to infertility and suggest a possible direction for future cytotherapy to infertility.http://dx.doi.org/10.1155/2021/8882368 |
| spellingShingle | Zhuo Chang Hui Zhu Xueming Zhou Yang Zhang Bei Jiang Shuoxi Li Lu Chen Xue Pan Xiao-ling Feng Mesenchymal Stem Cells in Preclinical Infertility Cytotherapy: A Retrospective Review Stem Cells International |
| title | Mesenchymal Stem Cells in Preclinical Infertility Cytotherapy: A Retrospective Review |
| title_full | Mesenchymal Stem Cells in Preclinical Infertility Cytotherapy: A Retrospective Review |
| title_fullStr | Mesenchymal Stem Cells in Preclinical Infertility Cytotherapy: A Retrospective Review |
| title_full_unstemmed | Mesenchymal Stem Cells in Preclinical Infertility Cytotherapy: A Retrospective Review |
| title_short | Mesenchymal Stem Cells in Preclinical Infertility Cytotherapy: A Retrospective Review |
| title_sort | mesenchymal stem cells in preclinical infertility cytotherapy a retrospective review |
| url | http://dx.doi.org/10.1155/2021/8882368 |
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