BMAL1-depletion remodels ceramide metabolism to regulate ferroptosis and sorafenib chemosensitivity in acute myeloid leukemia

BMAL1-depletion remodels ceramide metabolism to regulate ferroptosis and sorafenib chemosensitivity in acute myeloid leukemia

Summary: Acute myeloid leukemia (AML) is a hematologic malignancy with a poor prognosis. We discovered that BMAL1 is a ferroptosis suppressor. Furthermore, it was also found to be overexpressed in AML patients, affecting the cell cycle and promoting tumor cell growth and progression. In this study,...

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Bibliographic Details
Main Authors: Hong Zheng, Zhi Lin, Dan Wang, Jing Zhang, Ting Zeng, Jie Shen, Jia-Da Li, Minghua Yang
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Cancer
Lipidomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225003141
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