A human model to deconvolve genotype-phenotype causations in lung squamous cell carcinoma

A human model to deconvolve genotype-phenotype causations in lung squamous cell carcinoma

Abstract Tractable, patient-relevant models are needed to investigate cancer progression and heterogeneity. Here, we report an alternative in vitro model of lung squamous cell carcinoma (LUSC) using primary human bronchial epithelial cells (hBECs) from three healthy donors. The co-operation of ubiqu...

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Bibliographic Details
Main Authors: Julia Ogden, Robert Sellers, Sudhakar Sahoo, Anthony Oojageer, Anshuman Chaturvedi, Caroline Dive, Carlos Lopez-Garcia
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58343-y
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