Devaluing memories of reward: a case for dopamine
Abstract Midbrain dopamine cells encode differences in predictive and expected value to support learning through reward prediction error. Recent findings have questioned whether reward prediction error can fully account for dopamine function and suggest a more complex role for dopamine in encoding d...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07440-7 |
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| _version_ | 1823861709449723904 |
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| author | Benjamin R. Fry Nicolette Russell Victoria Fex Bing Mo Nathan Pence Joseph A. Beatty Fredric P. Manfredsson Brandon A. Toth Christian R. Burgess Samuel Gershman Alexander W. Johnson |
| author_facet | Benjamin R. Fry Nicolette Russell Victoria Fex Bing Mo Nathan Pence Joseph A. Beatty Fredric P. Manfredsson Brandon A. Toth Christian R. Burgess Samuel Gershman Alexander W. Johnson |
| author_sort | Benjamin R. Fry |
| collection | DOAJ |
| description | Abstract Midbrain dopamine cells encode differences in predictive and expected value to support learning through reward prediction error. Recent findings have questioned whether reward prediction error can fully account for dopamine function and suggest a more complex role for dopamine in encoding detailed features of the reward environment. In this series of studies, we describe a novel role for dopamine in devaluing sensory features of reward. Mesencephalic dopamine cells activated during a mediated devaluation phase were later chemogenetically reactivated. This retrieval of the devalued reward memory elicited a reduction in the hedonic evaluation of sucrose reward. Through optogenetic and chemogenetic manipulations, we confirm dopamine cells are both sufficient and necessary for mediated devaluation, and retrieval of these memories reflected dopamine release in the nucleus accumbens. Consistent with our computational modeling data, our findings indicate a critical role for dopamine in encoding predictive representations of the sensory features of reinforcement. Overall, we elucidate a novel role for dopamine function in mediated devaluation and illuminate a more elaborate framework through which dopamine encodes reinforcement signals. |
| format | Article |
| id | doaj-art-3246aa60f496450088c2c2e49c0eb74e |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-3246aa60f496450088c2c2e49c0eb74e2025-02-09T12:50:33ZengNature PortfolioCommunications Biology2399-36422025-02-018111110.1038/s42003-024-07440-7Devaluing memories of reward: a case for dopamineBenjamin R. Fry0Nicolette Russell1Victoria Fex2Bing Mo3Nathan Pence4Joseph A. Beatty5Fredric P. Manfredsson6Brandon A. Toth7Christian R. Burgess8Samuel Gershman9Alexander W. Johnson10Department of Psychology, Michigan State UniversityDepartment of Psychology, Michigan State UniversityLyman Briggs College, Michigan State UniversityDepartment of Psychology, Michigan State UniversityDepartment of Psychology, Michigan State UniversityDepartment of Physiology, Michigan State UniversityDepartment of Translational Neuroscience, Barrow Neurological InstituteMichigan Neuroscience Institute, University of MichiganMichigan Neuroscience Institute, University of MichiganDepartment of Psychology, Harvard UniversityDepartment of Psychology, Michigan State UniversityAbstract Midbrain dopamine cells encode differences in predictive and expected value to support learning through reward prediction error. Recent findings have questioned whether reward prediction error can fully account for dopamine function and suggest a more complex role for dopamine in encoding detailed features of the reward environment. In this series of studies, we describe a novel role for dopamine in devaluing sensory features of reward. Mesencephalic dopamine cells activated during a mediated devaluation phase were later chemogenetically reactivated. This retrieval of the devalued reward memory elicited a reduction in the hedonic evaluation of sucrose reward. Through optogenetic and chemogenetic manipulations, we confirm dopamine cells are both sufficient and necessary for mediated devaluation, and retrieval of these memories reflected dopamine release in the nucleus accumbens. Consistent with our computational modeling data, our findings indicate a critical role for dopamine in encoding predictive representations of the sensory features of reinforcement. Overall, we elucidate a novel role for dopamine function in mediated devaluation and illuminate a more elaborate framework through which dopamine encodes reinforcement signals.https://doi.org/10.1038/s42003-024-07440-7 |
| spellingShingle | Benjamin R. Fry Nicolette Russell Victoria Fex Bing Mo Nathan Pence Joseph A. Beatty Fredric P. Manfredsson Brandon A. Toth Christian R. Burgess Samuel Gershman Alexander W. Johnson Devaluing memories of reward: a case for dopamine Communications Biology |
| title | Devaluing memories of reward: a case for dopamine |
| title_full | Devaluing memories of reward: a case for dopamine |
| title_fullStr | Devaluing memories of reward: a case for dopamine |
| title_full_unstemmed | Devaluing memories of reward: a case for dopamine |
| title_short | Devaluing memories of reward: a case for dopamine |
| title_sort | devaluing memories of reward a case for dopamine |
| url | https://doi.org/10.1038/s42003-024-07440-7 |
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