Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin
One of the most prevalent complications of pregnancy is preeclampsia, a hypertensive disorder which is a leading cause of maternal and perinatal morbidity and premature birth with no effective pharmacological intervention. While the underlying cause is unclear, it is believed that placental ischemi...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2012/486053 |
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| author | Eric M. George Drew Colson Jeremy Dixon Ana C. Palei Joey P. Granger |
| author_facet | Eric M. George Drew Colson Jeremy Dixon Ana C. Palei Joey P. Granger |
| author_sort | Eric M. George |
| collection | DOAJ |
| description | One of the most prevalent complications of pregnancy is preeclampsia, a hypertensive disorder which is a leading cause of maternal and perinatal morbidity and premature birth with no effective pharmacological intervention. While the underlying cause is unclear, it is believed that placental ischemia/hypoxia induces the release of factors into the maternal vasculature and lead to widespread maternal endothelial dysfunction. Recently, HO-1 has been shown to downregulate two of these factors, reactive oxygen species and sFlt-1, and we have reported that HO-1 induction attenuates many of the pathological factors of placental ischemia experimentally. Here, we have examined the direct effect of HO-1 and its bioactive metabolites on hypoxia-induced changes in superoxide and sFlt-1 in placental vascular explants and showed that HO-1 and its metabolites attenuate the production of both factors in this system. These findings suggest that the HO-1 pathway may be a promising therapeutic approach for the treatment of preeclampsia. |
| format | Article |
| id | doaj-art-324670a97a404be58d0bcda07bb144a5 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-324670a97a404be58d0bcda07bb144a52025-08-20T03:55:03ZengWileyInternational Journal of Hypertension2090-03842090-03922012-01-01201210.1155/2012/486053486053Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and BilirubinEric M. George0Drew Colson1Jeremy Dixon2Ana C. Palei3Joey P. Granger4Department of Physiology and Biophysics and Center for Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center, Jackson, MS 39216, USADepartment of Physiology and Biophysics and Center for Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center, Jackson, MS 39216, USADepartment of Physiology and Biophysics and Center for Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center, Jackson, MS 39216, USADepartment of Physiology and Biophysics and Center for Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center, Jackson, MS 39216, USADepartment of Physiology and Biophysics and Center for Excellence in Cardiovascular-Renal Research, The University of Mississippi Medical Center, Jackson, MS 39216, USAOne of the most prevalent complications of pregnancy is preeclampsia, a hypertensive disorder which is a leading cause of maternal and perinatal morbidity and premature birth with no effective pharmacological intervention. While the underlying cause is unclear, it is believed that placental ischemia/hypoxia induces the release of factors into the maternal vasculature and lead to widespread maternal endothelial dysfunction. Recently, HO-1 has been shown to downregulate two of these factors, reactive oxygen species and sFlt-1, and we have reported that HO-1 induction attenuates many of the pathological factors of placental ischemia experimentally. Here, we have examined the direct effect of HO-1 and its bioactive metabolites on hypoxia-induced changes in superoxide and sFlt-1 in placental vascular explants and showed that HO-1 and its metabolites attenuate the production of both factors in this system. These findings suggest that the HO-1 pathway may be a promising therapeutic approach for the treatment of preeclampsia.http://dx.doi.org/10.1155/2012/486053 |
| spellingShingle | Eric M. George Drew Colson Jeremy Dixon Ana C. Palei Joey P. Granger Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin International Journal of Hypertension |
| title | Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin |
| title_full | Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin |
| title_fullStr | Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin |
| title_full_unstemmed | Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin |
| title_short | Heme Oxygenase-1 Attenuates Hypoxia-Induced sFlt-1 and Oxidative Stress in Placental Villi through Its Metabolic Products CO and Bilirubin |
| title_sort | heme oxygenase 1 attenuates hypoxia induced sflt 1 and oxidative stress in placental villi through its metabolic products co and bilirubin |
| url | http://dx.doi.org/10.1155/2012/486053 |
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