Investigation of Association with First-Trimester Free Human Chorionic Gonadotropin-ß, Pregnancy - Associated Plasma Protein-A, and Adverse Pregnancy Outcomes
OBJECTIVES: This study aimed to investigate the association between first-trimester screening maternal serum markers (free human chorionic gonadotropin-beta (β-hCG), pregnancy-associated plasma protein-A, and adverse pregnancy outcomes (gestational hypertension, preeclampsia, preterm delivery, intr...
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Medical Network
2022-03-01
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| Series: | Gynecology Obstetrics & Reproductive Medicine |
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| Online Access: | https://gorm.com.tr/index.php/GORM/article/view/1158 |
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| author | Gokhan Gonen Yasam Kemal Akpak Murat Muhcu |
| author_facet | Gokhan Gonen Yasam Kemal Akpak Murat Muhcu |
| author_sort | Gokhan Gonen |
| collection | DOAJ |
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OBJECTIVES: This study aimed to investigate the association between first-trimester screening maternal serum markers (free human chorionic gonadotropin-beta (β-hCG), pregnancy-associated plasma protein-A, and adverse pregnancy outcomes (gestational hypertension, preeclampsia, preterm delivery, intrauterine growth restriction, oligohydramnios, intrauterine ex-fetus, abruptio placentae, and gestational diabetes mellitus).
STUDY DESIGN: This was a retrospective cohort study including 1516 women who delivered a singleton pregnancy at GATA Haydarpasa Education Hospital from 2006 to 2009. Patients with multiple pregnancies, chromosome aberrations, or fetal anomalies were excluded. Extreme values of corrected- pregnancy-associated plasma protein-A and free β-hCG, and their association with adverse pregnancy outcomes were analyzed.
RESULTS: Adverse pregnancy outcomes at the cutoff level of ≤0.25 c-pregnancy-associated plasma protein-A MOM values positive likelihood ratio (+LR) was 7.5 (95%CI 2.426-19.836) and had a significant correlation (r=0.108, p<0.01). It was also a significant correlation with adverse pregnancy outcomes (r=0.189, p<0.01) at the cut-off level of ≤0.50 corrected-pregnancy-associated plasma protein-A MOM values and the +LR was 2.388 (95%CI 1.889-2.991). Association between low corrected-pregnancy-associated plasma protein-A MOM values and adverse pregnancy outcomes were statistically significant and had a poor association (AUC, 0.630 95%CI 0.596-0.663, p<0.01). Preeclampsia was statistically significant, however had a fair association (AUC, 0.74 95% CI 0.690-0.802, p<0.01). Preterm birth was statistically significant but had a poor association (AUC, 0.568 95% CI 0.512-0.624, p<0.05).
CONCLUSION: First-trimester maternal serum low pregnancy-associated plasma protein-A values are significantly associated with adverse pregnancy outcomes. It may be a useful tool to predictive not only chromosome anomalies but also adverse pregnancy outcomes.
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| format | Article |
| id | doaj-art-324254dfdb494252a1af337c1130dd0e |
| institution | Kabale University |
| issn | 1300-4751 2602-4918 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Medical Network |
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| series | Gynecology Obstetrics & Reproductive Medicine |
| spelling | doaj-art-324254dfdb494252a1af337c1130dd0e2025-02-11T21:14:44ZengMedical NetworkGynecology Obstetrics & Reproductive Medicine1300-47512602-49182022-03-0128110.21613/GORM.2021.1158Investigation of Association with First-Trimester Free Human Chorionic Gonadotropin-ß, Pregnancy - Associated Plasma Protein-A, and Adverse Pregnancy OutcomesGokhan Gonen0Yasam Kemal Akpak1Murat Muhcu2Şehit Sait ERTÜRK State Hospital, ETIMESGUT, ANKARADepartment of Obstetrics and Gynaecology, University of Health SciencesTepecik Training and Research Hospital, İzmir, TurkeyDepartment of Obstetrics and Gynaecology, University of Health Sciences Ümraniye Training and Research Hospital, İstanbul, Turkey OBJECTIVES: This study aimed to investigate the association between first-trimester screening maternal serum markers (free human chorionic gonadotropin-beta (β-hCG), pregnancy-associated plasma protein-A, and adverse pregnancy outcomes (gestational hypertension, preeclampsia, preterm delivery, intrauterine growth restriction, oligohydramnios, intrauterine ex-fetus, abruptio placentae, and gestational diabetes mellitus). STUDY DESIGN: This was a retrospective cohort study including 1516 women who delivered a singleton pregnancy at GATA Haydarpasa Education Hospital from 2006 to 2009. Patients with multiple pregnancies, chromosome aberrations, or fetal anomalies were excluded. Extreme values of corrected- pregnancy-associated plasma protein-A and free β-hCG, and their association with adverse pregnancy outcomes were analyzed. RESULTS: Adverse pregnancy outcomes at the cutoff level of ≤0.25 c-pregnancy-associated plasma protein-A MOM values positive likelihood ratio (+LR) was 7.5 (95%CI 2.426-19.836) and had a significant correlation (r=0.108, p<0.01). It was also a significant correlation with adverse pregnancy outcomes (r=0.189, p<0.01) at the cut-off level of ≤0.50 corrected-pregnancy-associated plasma protein-A MOM values and the +LR was 2.388 (95%CI 1.889-2.991). Association between low corrected-pregnancy-associated plasma protein-A MOM values and adverse pregnancy outcomes were statistically significant and had a poor association (AUC, 0.630 95%CI 0.596-0.663, p<0.01). Preeclampsia was statistically significant, however had a fair association (AUC, 0.74 95% CI 0.690-0.802, p<0.01). Preterm birth was statistically significant but had a poor association (AUC, 0.568 95% CI 0.512-0.624, p<0.05). CONCLUSION: First-trimester maternal serum low pregnancy-associated plasma protein-A values are significantly associated with adverse pregnancy outcomes. It may be a useful tool to predictive not only chromosome anomalies but also adverse pregnancy outcomes. https://gorm.com.tr/index.php/GORM/article/view/1158Fetal growth restrictionGestational hypertensionHuman chorionic gonadotrophin beta subunitNuchal translucencyPreeclampsiaPregnancy-associated plasma protein A |
| spellingShingle | Gokhan Gonen Yasam Kemal Akpak Murat Muhcu Investigation of Association with First-Trimester Free Human Chorionic Gonadotropin-ß, Pregnancy - Associated Plasma Protein-A, and Adverse Pregnancy Outcomes Gynecology Obstetrics & Reproductive Medicine Fetal growth restriction Gestational hypertension Human chorionic gonadotrophin beta subunit Nuchal translucency Preeclampsia Pregnancy-associated plasma protein A |
| title | Investigation of Association with First-Trimester Free Human Chorionic Gonadotropin-ß, Pregnancy - Associated Plasma Protein-A, and Adverse Pregnancy Outcomes |
| title_full | Investigation of Association with First-Trimester Free Human Chorionic Gonadotropin-ß, Pregnancy - Associated Plasma Protein-A, and Adverse Pregnancy Outcomes |
| title_fullStr | Investigation of Association with First-Trimester Free Human Chorionic Gonadotropin-ß, Pregnancy - Associated Plasma Protein-A, and Adverse Pregnancy Outcomes |
| title_full_unstemmed | Investigation of Association with First-Trimester Free Human Chorionic Gonadotropin-ß, Pregnancy - Associated Plasma Protein-A, and Adverse Pregnancy Outcomes |
| title_short | Investigation of Association with First-Trimester Free Human Chorionic Gonadotropin-ß, Pregnancy - Associated Plasma Protein-A, and Adverse Pregnancy Outcomes |
| title_sort | investigation of association with first trimester free human chorionic gonadotropin ss pregnancy associated plasma protein a and adverse pregnancy outcomes |
| topic | Fetal growth restriction Gestational hypertension Human chorionic gonadotrophin beta subunit Nuchal translucency Preeclampsia Pregnancy-associated plasma protein A |
| url | https://gorm.com.tr/index.php/GORM/article/view/1158 |
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