The role of microglia in Zika virus pathogenesis: Possible diagnostic and therapeutic strategies
The Zika virus, a member of the Flaviviridae family, is a mosquito-borne disease-causing virus that gained worldwide attention after a severe outbreak in Brazil in 2015. During this outbreak, some alarming evidence suggests that fetal microcephaly and other neuro-developmental disorders were associa...
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| Language: | English |
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Elsevier
2024-12-01
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| Series: | The Microbe |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S295019462400147X |
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| author | Subhrajyoti Paul Sudipta Patra Ayan Mondal Gungun Sharma Adhikari Piu Ghosh Manojit Bysack Rajen Dey |
| author_facet | Subhrajyoti Paul Sudipta Patra Ayan Mondal Gungun Sharma Adhikari Piu Ghosh Manojit Bysack Rajen Dey |
| author_sort | Subhrajyoti Paul |
| collection | DOAJ |
| description | The Zika virus, a member of the Flaviviridae family, is a mosquito-borne disease-causing virus that gained worldwide attention after a severe outbreak in Brazil in 2015. During this outbreak, some alarming evidence suggests that fetal microcephaly and other neuro-developmental disorders were associated with Zika infection. The virus also causes multi-organ failure and thrombocytopenia and also affects the eyes, leading to a potentially inflammatory disease called uveitis in adult individuals. It could be transmitted through sexual intercourse or the transplacental route, which is not commonly observed in other flaviviruses. In this review, we are interested in discovering the specific role of microglia in the pathogenesis of Zika virus-induced neuroinflammation. The virus comes into contact with microglial cells through the blood and causes activation and neuroinflammatory consequences, leading to the death of developing neurons and ultimately resulting in altered neuron-glia interaction. Despite its severity, there is still no specific medicine or vaccine available to combat the Zika infection. An essential aspect of this review is to identify cost-effective treatment strategies and accurate diagnostic methods for broader populations. In conclusion, an understanding of the cellular basis of Zika pathogenesis can help ensure potential treatment strategies to combat the global outbreak of the Zika virus. |
| format | Article |
| id | doaj-art-323d11b2ad424c4c8ce627f40fc4503f |
| institution | DOAJ |
| issn | 2950-1946 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Microbe |
| spelling | doaj-art-323d11b2ad424c4c8ce627f40fc4503f2025-08-20T02:48:57ZengElsevierThe Microbe2950-19462024-12-01510018010.1016/j.microb.2024.100180The role of microglia in Zika virus pathogenesis: Possible diagnostic and therapeutic strategiesSubhrajyoti Paul0Sudipta Patra1Ayan Mondal2Gungun Sharma Adhikari3Piu Ghosh4Manojit Bysack5Rajen Dey6Department of Medical Laboratory Technology, School of Allied Health Sciences, Swami Vivekananda University, Telinipara, Barasat-Barrackpore Rd, Bara Kanthalia, West Bengal 700121, IndiaDepartment of Medical Laboratory Technology, School of Allied Health Sciences, Swami Vivekananda University, Telinipara, Barasat-Barrackpore Rd, Bara Kanthalia, West Bengal 700121, IndiaDepartment of Medical Laboratory Technology, School of Allied Health Sciences, Swami Vivekananda University, Telinipara, Barasat-Barrackpore Rd, Bara Kanthalia, West Bengal 700121, IndiaDepartment of Medical Laboratory Technology, School of Allied Health Sciences, Swami Vivekananda University, Telinipara, Barasat-Barrackpore Rd, Bara Kanthalia, West Bengal 700121, IndiaDepartment of Medical Laboratory Technology, School of Allied Health Sciences, Swami Vivekananda University, Telinipara, Barasat-Barrackpore Rd, Bara Kanthalia, West Bengal 700121, IndiaDepartment of Medical Laboratory Technology, School of Allied Health Sciences, Swami Vivekananda University, Telinipara, Barasat-Barrackpore Rd, Bara Kanthalia, West Bengal 700121, IndiaCorresponding author.; Department of Medical Laboratory Technology, School of Allied Health Sciences, Swami Vivekananda University, Telinipara, Barasat-Barrackpore Rd, Bara Kanthalia, West Bengal 700121, IndiaThe Zika virus, a member of the Flaviviridae family, is a mosquito-borne disease-causing virus that gained worldwide attention after a severe outbreak in Brazil in 2015. During this outbreak, some alarming evidence suggests that fetal microcephaly and other neuro-developmental disorders were associated with Zika infection. The virus also causes multi-organ failure and thrombocytopenia and also affects the eyes, leading to a potentially inflammatory disease called uveitis in adult individuals. It could be transmitted through sexual intercourse or the transplacental route, which is not commonly observed in other flaviviruses. In this review, we are interested in discovering the specific role of microglia in the pathogenesis of Zika virus-induced neuroinflammation. The virus comes into contact with microglial cells through the blood and causes activation and neuroinflammatory consequences, leading to the death of developing neurons and ultimately resulting in altered neuron-glia interaction. Despite its severity, there is still no specific medicine or vaccine available to combat the Zika infection. An essential aspect of this review is to identify cost-effective treatment strategies and accurate diagnostic methods for broader populations. In conclusion, an understanding of the cellular basis of Zika pathogenesis can help ensure potential treatment strategies to combat the global outbreak of the Zika virus.http://www.sciencedirect.com/science/article/pii/S295019462400147XCytokineMicrocephalyMicrogliaNeuroinflammationZika virus |
| spellingShingle | Subhrajyoti Paul Sudipta Patra Ayan Mondal Gungun Sharma Adhikari Piu Ghosh Manojit Bysack Rajen Dey The role of microglia in Zika virus pathogenesis: Possible diagnostic and therapeutic strategies The Microbe Cytokine Microcephaly Microglia Neuroinflammation Zika virus |
| title | The role of microglia in Zika virus pathogenesis: Possible diagnostic and therapeutic strategies |
| title_full | The role of microglia in Zika virus pathogenesis: Possible diagnostic and therapeutic strategies |
| title_fullStr | The role of microglia in Zika virus pathogenesis: Possible diagnostic and therapeutic strategies |
| title_full_unstemmed | The role of microglia in Zika virus pathogenesis: Possible diagnostic and therapeutic strategies |
| title_short | The role of microglia in Zika virus pathogenesis: Possible diagnostic and therapeutic strategies |
| title_sort | role of microglia in zika virus pathogenesis possible diagnostic and therapeutic strategies |
| topic | Cytokine Microcephaly Microglia Neuroinflammation Zika virus |
| url | http://www.sciencedirect.com/science/article/pii/S295019462400147X |
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