Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase
Leprosy is a chronic disease caused by Mycobacterium leprae and affects the skin and the peripheral nervous system. Butyrylcholinesterase is coded by the BCHE gene, and the atypical allele (70G; rs1799807) has been investigated as a leprosy risk factor, with conflicting results. The present study es...
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Wiley
2012-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/184819 |
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| author | Henrique J. P. Gomes Ricardo L. R. Souza Flávia Costa Prevedello Marcelo Távora Mira Eleidi A. Chautard-Freire-Maia |
| author_facet | Henrique J. P. Gomes Ricardo L. R. Souza Flávia Costa Prevedello Marcelo Távora Mira Eleidi A. Chautard-Freire-Maia |
| author_sort | Henrique J. P. Gomes |
| collection | DOAJ |
| description | Leprosy is a chronic disease caused by Mycobacterium leprae and affects the skin and the peripheral nervous system. Butyrylcholinesterase is coded by the BCHE gene, and the atypical allele (70G; rs1799807) has been investigated as a leprosy risk factor, with conflicting results. The present study estimated the frequencies of variants of rs1799807 and of five additional SNPs at the BCHE gene or near it: rs1126680, rs1803274, rs2863381, rs4440084, and rs4387996. A total of 167 patients and 150 healthy controls were genotyped by TaqMan PCR. Significantly higher allelic (70G) and genotypic (70DG) frequencies in rs1799807 were found in the patient group, with odds ratio (OR) of 6.33 (1.40 to 28.53) for the heterozygote. This finding was replicated in a comparison of the cases against a control group of 361 blood donors. The present data suggest that the atypical BChE variant may predispose to leprosy per se. |
| format | Article |
| id | doaj-art-323ced34ee5543a290db738ab49243fb |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-323ced34ee5543a290db738ab49243fb2025-08-20T03:55:03ZengWileyJournal of Tropical Medicine1687-96861687-96942012-01-01201210.1155/2012/184819184819Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of ButyrylcholinesteraseHenrique J. P. Gomes0Ricardo L. R. Souza1Flávia Costa Prevedello2Marcelo Távora Mira3Eleidi A. Chautard-Freire-Maia4Department of Genetics, Federal University of Paraná, P.O. Box 19071, 81531-980 Curitiba, PR, BrazilDepartment of Genetics, Federal University of Paraná, P.O. Box 19071, 81531-980 Curitiba, PR, BrazilCore for Advanced Molecular Investigation, Medical School, Pontifical Catholic University of Paraná, Imaculada Conceição, 1155, 80215-901 Curitiba, PR, BrazilCore for Advanced Molecular Investigation, Medical School, Pontifical Catholic University of Paraná, Imaculada Conceição, 1155, 80215-901 Curitiba, PR, BrazilDepartment of Genetics, Federal University of Paraná, P.O. Box 19071, 81531-980 Curitiba, PR, BrazilLeprosy is a chronic disease caused by Mycobacterium leprae and affects the skin and the peripheral nervous system. Butyrylcholinesterase is coded by the BCHE gene, and the atypical allele (70G; rs1799807) has been investigated as a leprosy risk factor, with conflicting results. The present study estimated the frequencies of variants of rs1799807 and of five additional SNPs at the BCHE gene or near it: rs1126680, rs1803274, rs2863381, rs4440084, and rs4387996. A total of 167 patients and 150 healthy controls were genotyped by TaqMan PCR. Significantly higher allelic (70G) and genotypic (70DG) frequencies in rs1799807 were found in the patient group, with odds ratio (OR) of 6.33 (1.40 to 28.53) for the heterozygote. This finding was replicated in a comparison of the cases against a control group of 361 blood donors. The present data suggest that the atypical BChE variant may predispose to leprosy per se.http://dx.doi.org/10.1155/2012/184819 |
| spellingShingle | Henrique J. P. Gomes Ricardo L. R. Souza Flávia Costa Prevedello Marcelo Távora Mira Eleidi A. Chautard-Freire-Maia Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase Journal of Tropical Medicine |
| title | Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase |
| title_full | Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase |
| title_fullStr | Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase |
| title_full_unstemmed | Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase |
| title_short | Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase |
| title_sort | investigation of association between susceptibility to leprosy and snps inside and near the bche gene of butyrylcholinesterase |
| url | http://dx.doi.org/10.1155/2012/184819 |
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