Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential
Resveratrol, a polyphenolic compound known for its diverse biological activities, has demonstrated multiple pharmacological effects, including anti-inflammatory, anti-aging, anti-diabetic, anti-cancer, and cardiovascular protective properties. Recent studies suggest that these effects are partly med...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1516609/full |
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| author | Panting Wang Panting Wang Zixi Li Yixuan Song Bowei Zhang Chaofeng Fan Chaofeng Fan |
| author_facet | Panting Wang Panting Wang Zixi Li Yixuan Song Bowei Zhang Chaofeng Fan Chaofeng Fan |
| author_sort | Panting Wang |
| collection | DOAJ |
| description | Resveratrol, a polyphenolic compound known for its diverse biological activities, has demonstrated multiple pharmacological effects, including anti-inflammatory, anti-aging, anti-diabetic, anti-cancer, and cardiovascular protective properties. Recent studies suggest that these effects are partly mediated through the regulation of macrophage polarization, wherein macrophages differentiate into pro-inflammatory M1 or anti-inflammatory M2 phenotypes. Our review highlights how resveratrol modulates macrophage polarization through various signaling pathways to achieve therapeutic effects. For example, resveratrol can activate the senescence-associated secretory phenotype (SASP) pathway and inhibit the signal transducer and activator of transcription (STAT3) and sphingosine-1-phosphate (S1P)-YAP signaling axes, promoting M1 polarization or suppressing M2 polarization, thereby inhibiting tumor growth. Conversely, it can promote M2 polarization or suppress M1 polarization by inhibiting the NF-κB signaling pathway or activating the PI3K/Akt and AMP-activated protein kinase (AMPK) pathways, thus alleviating inflammatory responses. Notably, the effect of resveratrol on macrophage polarization is concentration-dependent; moderate concentrations tend to promote M1 polarization, while higher concentrations may favor M2 polarization. This concentration dependence offers new perspectives for clinical treatment but also underscores the necessity for precise dosage control when using resveratrol. In summary, resveratrol exhibits significant potential in regulating macrophage polarization and treating related diseases. |
| format | Article |
| id | doaj-art-323a07eab4644ec7a185485741804d3a |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-323a07eab4644ec7a185485741804d3a2025-01-13T11:07:30ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.15166091516609Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potentialPanting Wang0Panting Wang1Zixi Li2Yixuan Song3Bowei Zhang4Chaofeng Fan5Chaofeng Fan6Department of Neurosurgery West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Nursing Sichuan University, Chengdu, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSchool of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaSouthwest Institute of Technical Physics, Chengdu, ChinaDepartment of Neurosurgery West China Hospital, Sichuan University, Chengdu, ChinaWest China School of Nursing Sichuan University, Chengdu, ChinaResveratrol, a polyphenolic compound known for its diverse biological activities, has demonstrated multiple pharmacological effects, including anti-inflammatory, anti-aging, anti-diabetic, anti-cancer, and cardiovascular protective properties. Recent studies suggest that these effects are partly mediated through the regulation of macrophage polarization, wherein macrophages differentiate into pro-inflammatory M1 or anti-inflammatory M2 phenotypes. Our review highlights how resveratrol modulates macrophage polarization through various signaling pathways to achieve therapeutic effects. For example, resveratrol can activate the senescence-associated secretory phenotype (SASP) pathway and inhibit the signal transducer and activator of transcription (STAT3) and sphingosine-1-phosphate (S1P)-YAP signaling axes, promoting M1 polarization or suppressing M2 polarization, thereby inhibiting tumor growth. Conversely, it can promote M2 polarization or suppress M1 polarization by inhibiting the NF-κB signaling pathway or activating the PI3K/Akt and AMP-activated protein kinase (AMPK) pathways, thus alleviating inflammatory responses. Notably, the effect of resveratrol on macrophage polarization is concentration-dependent; moderate concentrations tend to promote M1 polarization, while higher concentrations may favor M2 polarization. This concentration dependence offers new perspectives for clinical treatment but also underscores the necessity for precise dosage control when using resveratrol. In summary, resveratrol exhibits significant potential in regulating macrophage polarization and treating related diseases.https://www.frontiersin.org/articles/10.3389/fphar.2024.1516609/fullresveratrolmacrophage polarizationM1/M2 phenotypescancerinflammation |
| spellingShingle | Panting Wang Panting Wang Zixi Li Yixuan Song Bowei Zhang Chaofeng Fan Chaofeng Fan Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential Frontiers in Pharmacology resveratrol macrophage polarization M1/M2 phenotypes cancer inflammation |
| title | Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential |
| title_full | Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential |
| title_fullStr | Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential |
| title_full_unstemmed | Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential |
| title_short | Resveratrol-driven macrophage polarization: unveiling mechanisms and therapeutic potential |
| title_sort | resveratrol driven macrophage polarization unveiling mechanisms and therapeutic potential |
| topic | resveratrol macrophage polarization M1/M2 phenotypes cancer inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1516609/full |
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