Thrombotic Complications in Inflammatory Bowel Disease
The risk of thrombotic complications is known to be 3 times higher in patients with inflammatory bowel disease (IBD) than in healthy individuals, with the relative risk being 15 times higher during the periods of relapses. Aim. To study and generalize literature data available on the prevention and...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2019-05-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/351 |
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| _version_ | 1823860117757493248 |
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| author | A. V. Borota A. A. Borota E. V. Onishchenko |
| author_facet | A. V. Borota A. A. Borota E. V. Onishchenko |
| author_sort | A. V. Borota |
| collection | DOAJ |
| description | The risk of thrombotic complications is known to be 3 times higher in patients with inflammatory bowel disease (IBD) than in healthy individuals, with the relative risk being 15 times higher during the periods of relapses. Aim. To study and generalize literature data available on the prevention and treatment of IBD thrombotic complications.Key findings. In the сonditions under study, the presence of chronic inflammation and increased bleeding of the intestinal wall is shown to activate the coagulation system, impair the fibrinolysis system and reduce the activity of natural anticoagulation mechanisms. The concentration of fibrinogen — a protein of the acute inflammation phase — increases significantly. This results in an imbalance of the blood coagulation system with a tendency to hypercoagulation, which significantly increases the risk of thrombotic complications and the disseminated intravascular coagulation syndrome. In turn, the activation of the coagulation cascade may trigger the inflammatory response, which eventually leads to the formation of a vicious circle between chronic inflammation and thrombosis. The pathogenesis of thrombosis in inflammatory colon diseases is a multifactor process, which remains to be understood.Conclusion.The management of patients with IBD in combination with thromboembolic complications requires an individual multidisciplinary approach. Taking into account the pathogenetic factors, the following options are possible in the prevention and treatment of thrombotic complications in IBD: strengthening the basic therapy of the primary disease; administration of prophylactic doses of anticoagulants under dynamic continuous laboratory control in the acute period using the methods of conservative therapy of thrombotic complications (elastic compression of the lower extremities) in the period of exacerbation of the primary disease. |
| format | Article |
| id | doaj-art-32390be9adbf4e6fa09afdf52778a7f6 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2019-05-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-32390be9adbf4e6fa09afdf52778a7f62025-02-10T16:14:35ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732019-05-01292232610.22416/1382-4376-2019-29-2-23-26300Thrombotic Complications in Inflammatory Bowel DiseaseA. V. Borota0A. A. Borota1E. V. Onishchenko2M. Gorky Donetsk National Medical UniversityM. Gorky Donetsk National Medical UniversityM. Gorky Donetsk National Medical UniversityThe risk of thrombotic complications is known to be 3 times higher in patients with inflammatory bowel disease (IBD) than in healthy individuals, with the relative risk being 15 times higher during the periods of relapses. Aim. To study and generalize literature data available on the prevention and treatment of IBD thrombotic complications.Key findings. In the сonditions under study, the presence of chronic inflammation and increased bleeding of the intestinal wall is shown to activate the coagulation system, impair the fibrinolysis system and reduce the activity of natural anticoagulation mechanisms. The concentration of fibrinogen — a protein of the acute inflammation phase — increases significantly. This results in an imbalance of the blood coagulation system with a tendency to hypercoagulation, which significantly increases the risk of thrombotic complications and the disseminated intravascular coagulation syndrome. In turn, the activation of the coagulation cascade may trigger the inflammatory response, which eventually leads to the formation of a vicious circle between chronic inflammation and thrombosis. The pathogenesis of thrombosis in inflammatory colon diseases is a multifactor process, which remains to be understood.Conclusion.The management of patients with IBD in combination with thromboembolic complications requires an individual multidisciplinary approach. Taking into account the pathogenetic factors, the following options are possible in the prevention and treatment of thrombotic complications in IBD: strengthening the basic therapy of the primary disease; administration of prophylactic doses of anticoagulants under dynamic continuous laboratory control in the acute period using the methods of conservative therapy of thrombotic complications (elastic compression of the lower extremities) in the period of exacerbation of the primary disease.https://www.gastro-j.ru/jour/article/view/351ulcerative colitiscrohn’s diseasethrombosis |
| spellingShingle | A. V. Borota A. A. Borota E. V. Onishchenko Thrombotic Complications in Inflammatory Bowel Disease Российский журнал гастроэнтерологии, гепатологии, колопроктологии ulcerative colitis crohn’s disease thrombosis |
| title | Thrombotic Complications in Inflammatory Bowel Disease |
| title_full | Thrombotic Complications in Inflammatory Bowel Disease |
| title_fullStr | Thrombotic Complications in Inflammatory Bowel Disease |
| title_full_unstemmed | Thrombotic Complications in Inflammatory Bowel Disease |
| title_short | Thrombotic Complications in Inflammatory Bowel Disease |
| title_sort | thrombotic complications in inflammatory bowel disease |
| topic | ulcerative colitis crohn’s disease thrombosis |
| url | https://www.gastro-j.ru/jour/article/view/351 |
| work_keys_str_mv | AT avborota thromboticcomplicationsininflammatoryboweldisease AT aaborota thromboticcomplicationsininflammatoryboweldisease AT evonishchenko thromboticcomplicationsininflammatoryboweldisease |