Transcriptomic analysis of rat prefrontal cortex following chronic stress induced by social isolation – Relevance to psychiatric and neurodevelopmental illness, and implications for treatment

Transcriptomic analysis of rat prefrontal cortex following chronic stress induced by social isolation – Relevance to psychiatric and neurodevelopmental illness, and implications for treatment

Social isolation is an established risk factor for psychiatric illness, and became increasingly topical with the spread of SARS-CoV-2. We used RNA sequencing (RNA-Seq) to enable unbiased assessment of transcriptomic changes within the prefrontal cortex (PFC) of isolation-reared rats. To provide insi...

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Bibliographic Details
Main Authors: Jen-Yin Goh, Patricia Rueda, Joy Taylor, Alex Rathbone, Daniel Scott, Christopher J. Langmead, Kevin C.F. Fone, Gregory D. Stewart, Madeleine V. King
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Neurobiology of Stress
Subjects:
Stress
Social isolation
Rat
Gene expression
Prefrontal cortex
Muscarinic M4 receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289524000754
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