Effects of topical application of metronidazole-containing mucoadhesive lipogel in periodontal pockets
Introduction. Metronidazole is the drug of choice in the treatment of periodontal pockets up to 5 mm in depth. It is topically applied - directly into the periodontal pockets. There are no registred trademark preparations for this purpose in the market of Serbia and Montenegro. The aim of our latest...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2005-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500508565T.pdf |
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| author | Toskić-Radojičić Marija Nonković Zorka Lončar Irma Varjačić Milomir |
| author_facet | Toskić-Radojičić Marija Nonković Zorka Lončar Irma Varjačić Milomir |
| author_sort | Toskić-Radojičić Marija |
| collection | DOAJ |
| description | Introduction. Metronidazole is the drug of choice in the treatment of periodontal pockets up to 5 mm in depth. It is topically applied - directly into the periodontal pockets. There are no registred trademark preparations for this purpose in the market of Serbia and Montenegro. The aim of our latest research was to test the efficacy of newly formulated preparation containing 25% metronidazole suspended in a lipogel in vitro - in anaerobic cultures isolated from the periodontal pockets, and in vivo - by the direct application into periodontal pockets. Methods. Preparation efficacy was tested in a randomized controlled study involving 25 patients, and was confirmed by the membrane-free agar diffusion method on the anaerobic strains isolated from the periodontal pockets. The duration of the testing was 30 days. The preparation was applied twice - immediately after the taking of the first swab, and on day 15, when the control swab was taken for the assessment of the effects of the applied preparation. Results. Seven anaerobic strains were isolated and tested, and each was confirmed as highly susceptible to metronidazole. Anaerobic strains were not isolated in any of the pockets treated with metronidazole-containing lipogel. The strains isolated in the control pockets were the same as were those at the beginning of the study. Conclusion. Metronidazole, in a lipogel-type base applied in the concentration of 25%, provided an efficient treatment of anaerobic infection in the periodontal pockets. |
| format | Article |
| id | doaj-art-3230e09f8dda477fa51aa8cbd383760b |
| institution | DOAJ |
| issn | 0042-8450 |
| language | English |
| publishDate | 2005-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-3230e09f8dda477fa51aa8cbd383760b2025-08-20T03:18:30ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502005-01-01627-856556810.2298/VSP0508565TEffects of topical application of metronidazole-containing mucoadhesive lipogel in periodontal pocketsToskić-Radojičić MarijaNonković ZorkaLončar IrmaVarjačić MilomirIntroduction. Metronidazole is the drug of choice in the treatment of periodontal pockets up to 5 mm in depth. It is topically applied - directly into the periodontal pockets. There are no registred trademark preparations for this purpose in the market of Serbia and Montenegro. The aim of our latest research was to test the efficacy of newly formulated preparation containing 25% metronidazole suspended in a lipogel in vitro - in anaerobic cultures isolated from the periodontal pockets, and in vivo - by the direct application into periodontal pockets. Methods. Preparation efficacy was tested in a randomized controlled study involving 25 patients, and was confirmed by the membrane-free agar diffusion method on the anaerobic strains isolated from the periodontal pockets. The duration of the testing was 30 days. The preparation was applied twice - immediately after the taking of the first swab, and on day 15, when the control swab was taken for the assessment of the effects of the applied preparation. Results. Seven anaerobic strains were isolated and tested, and each was confirmed as highly susceptible to metronidazole. Anaerobic strains were not isolated in any of the pockets treated with metronidazole-containing lipogel. The strains isolated in the control pockets were the same as were those at the beginning of the study. Conclusion. Metronidazole, in a lipogel-type base applied in the concentration of 25%, provided an efficient treatment of anaerobic infection in the periodontal pockets.http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500508565T.pdfperiodontal pocketmetronidazoleadhesivesgels |
| spellingShingle | Toskić-Radojičić Marija Nonković Zorka Lončar Irma Varjačić Milomir Effects of topical application of metronidazole-containing mucoadhesive lipogel in periodontal pockets Vojnosanitetski Pregled periodontal pocket metronidazole adhesives gels |
| title | Effects of topical application of metronidazole-containing mucoadhesive lipogel in periodontal pockets |
| title_full | Effects of topical application of metronidazole-containing mucoadhesive lipogel in periodontal pockets |
| title_fullStr | Effects of topical application of metronidazole-containing mucoadhesive lipogel in periodontal pockets |
| title_full_unstemmed | Effects of topical application of metronidazole-containing mucoadhesive lipogel in periodontal pockets |
| title_short | Effects of topical application of metronidazole-containing mucoadhesive lipogel in periodontal pockets |
| title_sort | effects of topical application of metronidazole containing mucoadhesive lipogel in periodontal pockets |
| topic | periodontal pocket metronidazole adhesives gels |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2005/0042-84500508565T.pdf |
| work_keys_str_mv | AT toskicradojicicmarija effectsoftopicalapplicationofmetronidazolecontainingmucoadhesivelipogelinperiodontalpockets AT nonkoviczorka effectsoftopicalapplicationofmetronidazolecontainingmucoadhesivelipogelinperiodontalpockets AT loncarirma effectsoftopicalapplicationofmetronidazolecontainingmucoadhesivelipogelinperiodontalpockets AT varjacicmilomir effectsoftopicalapplicationofmetronidazolecontainingmucoadhesivelipogelinperiodontalpockets |