Core-in-cup/liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics, in vitro release, and mucoadhesive strength
Reduced bioavailability of azelnidipine is related to its poor aqueous solubility and extensive first-pass metabolism, which hinder its efficacy. These problems were addressed by implementing (1) a liquisol technique for promoting the dissolution rate in a controlled-release manner and (2) a core-in...
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| Format: | Article |
| Language: | English |
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Sciendo
2019-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2019-0022 |
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| author | Rashad Amira A. El-Helaly Sara Nageeb Abd El Rehim Randa T. El-Gazayerly Omaima N. |
| author_facet | Rashad Amira A. El-Helaly Sara Nageeb Abd El Rehim Randa T. El-Gazayerly Omaima N. |
| author_sort | Rashad Amira A. |
| collection | DOAJ |
| description | Reduced bioavailability of azelnidipine is related to its poor aqueous solubility and extensive first-pass metabolism, which hinder its efficacy. These problems were addressed by implementing (1) a liquisol technique for promoting the dissolution rate in a controlled-release manner and (2) a core-in-cup bucco-adhesive drug delivery system as an alternative to the oral route. A 33 factorial design was used to study the effects of polymer type (sodium carboxymethyl cellulose (CMC Na), chitosan, or Carbomer P940) concentration (5, 10 or 15 %) and preparation technique (simple mix, liquisol or wet granulation) on the dissolution and mucoadhesion of core-in-cup azelnidipine buccoadhesive tablets. Tablet micromeritics, swelling index, mucoadhesive strength and in vitro release were characterized. Statistical analyses of these factors show ed significant effects on the studied responses, where F#16 prepared by the liquisol technique and containing 15 % CMC Na was chosen with an overall desirability of 0.953. |
| format | Article |
| id | doaj-art-322d38b9899c4a72a3923611ac10c876 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-322d38b9899c4a72a3923611ac10c8762025-02-02T11:49:57ZengSciendoActa Pharmaceutica1846-95582019-09-0169338139810.2478/acph-2019-0022acph-2019-0022Core-in-cup/liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics, in vitro release, and mucoadhesive strengthRashad Amira A.0El-Helaly Sara Nageeb1Abd El Rehim Randa T.2El-Gazayerly Omaima N.3Mepaco-Medifood Pharmaceutical Company, El Sharkia, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Cairo, EgyptReduced bioavailability of azelnidipine is related to its poor aqueous solubility and extensive first-pass metabolism, which hinder its efficacy. These problems were addressed by implementing (1) a liquisol technique for promoting the dissolution rate in a controlled-release manner and (2) a core-in-cup bucco-adhesive drug delivery system as an alternative to the oral route. A 33 factorial design was used to study the effects of polymer type (sodium carboxymethyl cellulose (CMC Na), chitosan, or Carbomer P940) concentration (5, 10 or 15 %) and preparation technique (simple mix, liquisol or wet granulation) on the dissolution and mucoadhesion of core-in-cup azelnidipine buccoadhesive tablets. Tablet micromeritics, swelling index, mucoadhesive strength and in vitro release were characterized. Statistical analyses of these factors show ed significant effects on the studied responses, where F#16 prepared by the liquisol technique and containing 15 % CMC Na was chosen with an overall desirability of 0.953.https://doi.org/10.2478/acph-2019-0022azelnidipineliquisolcore-in-cupbuccoadhesive tabletstablet micromeriticsin vitro release |
| spellingShingle | Rashad Amira A. El-Helaly Sara Nageeb Abd El Rehim Randa T. El-Gazayerly Omaima N. Core-in-cup/liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics, in vitro release, and mucoadhesive strength Acta Pharmaceutica azelnidipine liquisol core-in-cup buccoadhesive tablets tablet micromeritics in vitro release |
| title | Core-in-cup/liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics, in vitro release, and mucoadhesive strength |
| title_full | Core-in-cup/liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics, in vitro release, and mucoadhesive strength |
| title_fullStr | Core-in-cup/liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics, in vitro release, and mucoadhesive strength |
| title_full_unstemmed | Core-in-cup/liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics, in vitro release, and mucoadhesive strength |
| title_short | Core-in-cup/liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics, in vitro release, and mucoadhesive strength |
| title_sort | core in cup liquisol dual tackling effect on azelnidipine buccoadhesive tablet micromeritics in vitro release and mucoadhesive strength |
| topic | azelnidipine liquisol core-in-cup buccoadhesive tablets tablet micromeritics in vitro release |
| url | https://doi.org/10.2478/acph-2019-0022 |
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