Update on the Complications and Management of Liver Cirrhosis
Liver cirrhosis represents the advanced pathological stage of chronic liver disease, characterized by the progressive destruction and regeneration of the hepatic parenchyma over years, culminating in fibrosis and disruption of the vascular architecture. As a leading global cause of morbidity and mor...
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MDPI AG
2025-02-01
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| Online Access: | https://www.mdpi.com/2076-3271/13/1/13 |
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| author | Hiba Fadlallah Diala El Masri Hisham F. Bahmad Wassim Abou-Kheir Jad El Masri |
| author_facet | Hiba Fadlallah Diala El Masri Hisham F. Bahmad Wassim Abou-Kheir Jad El Masri |
| author_sort | Hiba Fadlallah |
| collection | DOAJ |
| description | Liver cirrhosis represents the advanced pathological stage of chronic liver disease, characterized by the progressive destruction and regeneration of the hepatic parenchyma over years, culminating in fibrosis and disruption of the vascular architecture. As a leading global cause of morbidity and mortality, it continues to affect millions worldwide, imposing a substantial burden on healthcare systems. Alcoholic/nonalcoholic fatty liver disease and chronic viral hepatitis infection, hepatitis C (HCV) in particular, remain leading causes of cirrhosis. Despite significant advances in understanding the pathogenesis of cirrhosis, its management is still complex due to the multifaceted complications, including ascites, hepatic encephalopathy, variceal bleeding, and hepatocellular carcinoma, all of which severely compromise the patient outcomes and quality of life. This review aims at filling a critical gap by providing a comprehensive summary of the latest evidence on the complications and management of liver cirrhosis. Evidence-based therapies targeting both the etiologies and complications of cirrhosis are essential for improving outcomes. While liver transplantation is considered a definitive cure, advancements in pharmacological therapies offer promising avenues for halting and potentially reversing disease progression. This review summarizes the latest management strategies for cirrhosis and its associated complications, emphasizing the importance of early intervention and novel therapeutic options for improving outcomes and quality of life in affected individuals. |
| format | Article |
| id | doaj-art-322c8da270644002ad3f34676c73b45e |
| institution | DOAJ |
| issn | 2076-3271 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medical Sciences |
| spelling | doaj-art-322c8da270644002ad3f34676c73b45e2025-08-20T02:42:22ZengMDPI AGMedical Sciences2076-32712025-02-011311310.3390/medsci13010013Update on the Complications and Management of Liver CirrhosisHiba Fadlallah0Diala El Masri1Hisham F. Bahmad2Wassim Abou-Kheir3Jad El Masri4Department of Anatomy, Cell Biology, and Physiological Sciences, American University of Beirut, Beirut 1107-2020, LebanonFaculty of Medicine, University of Balamand, Al-Kurah, Tripoli P.O. Box 100, LebanonDepartment of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USADepartment of Anatomy, Cell Biology, and Physiological Sciences, American University of Beirut, Beirut 1107-2020, LebanonDepartment of Anatomy, Cell Biology, and Physiological Sciences, American University of Beirut, Beirut 1107-2020, LebanonLiver cirrhosis represents the advanced pathological stage of chronic liver disease, characterized by the progressive destruction and regeneration of the hepatic parenchyma over years, culminating in fibrosis and disruption of the vascular architecture. As a leading global cause of morbidity and mortality, it continues to affect millions worldwide, imposing a substantial burden on healthcare systems. Alcoholic/nonalcoholic fatty liver disease and chronic viral hepatitis infection, hepatitis C (HCV) in particular, remain leading causes of cirrhosis. Despite significant advances in understanding the pathogenesis of cirrhosis, its management is still complex due to the multifaceted complications, including ascites, hepatic encephalopathy, variceal bleeding, and hepatocellular carcinoma, all of which severely compromise the patient outcomes and quality of life. This review aims at filling a critical gap by providing a comprehensive summary of the latest evidence on the complications and management of liver cirrhosis. Evidence-based therapies targeting both the etiologies and complications of cirrhosis are essential for improving outcomes. While liver transplantation is considered a definitive cure, advancements in pharmacological therapies offer promising avenues for halting and potentially reversing disease progression. This review summarizes the latest management strategies for cirrhosis and its associated complications, emphasizing the importance of early intervention and novel therapeutic options for improving outcomes and quality of life in affected individuals.https://www.mdpi.com/2076-3271/13/1/13liver cirrhosischronic liver diseasecomplicationsmanagementtreatment |
| spellingShingle | Hiba Fadlallah Diala El Masri Hisham F. Bahmad Wassim Abou-Kheir Jad El Masri Update on the Complications and Management of Liver Cirrhosis Medical Sciences liver cirrhosis chronic liver disease complications management treatment |
| title | Update on the Complications and Management of Liver Cirrhosis |
| title_full | Update on the Complications and Management of Liver Cirrhosis |
| title_fullStr | Update on the Complications and Management of Liver Cirrhosis |
| title_full_unstemmed | Update on the Complications and Management of Liver Cirrhosis |
| title_short | Update on the Complications and Management of Liver Cirrhosis |
| title_sort | update on the complications and management of liver cirrhosis |
| topic | liver cirrhosis chronic liver disease complications management treatment |
| url | https://www.mdpi.com/2076-3271/13/1/13 |
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