Case Report: Transforming small cell lung cancer: two cases report and literature review
Transformation of non-small cell lung cancer (NSCLC) to small cell lung cancer (SCLC) is a relatively rare event with an incidence of about 3%-14%. Due to the poor treatment outcomes and prognosis associated with this transformation, understanding its underlying mechanisms is crucial for improving t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1573624/full |
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| author | Jinlong Liu Jinlong Liu Jing Ai Jing Ai Lize Zhao Yimeng Qian Yimeng Qian Qingxin Zhao Qingxin Zhao Chunling Ma Yu Zhao Jing Zhao |
| author_facet | Jinlong Liu Jinlong Liu Jing Ai Jing Ai Lize Zhao Yimeng Qian Yimeng Qian Qingxin Zhao Qingxin Zhao Chunling Ma Yu Zhao Jing Zhao |
| author_sort | Jinlong Liu |
| collection | DOAJ |
| description | Transformation of non-small cell lung cancer (NSCLC) to small cell lung cancer (SCLC) is a relatively rare event with an incidence of about 3%-14%. Due to the poor treatment outcomes and prognosis associated with this transformation, understanding its underlying mechanisms is crucial for improving the diagnosis, management, and prognosis of transformed small cell lung cancer (T-SCLC). In this paper, we present two cases of T-SCLC and review the molecular mechanisms, clinical features, and treatment strategies post-transformation. We emphasize the importance of considering pathological transformation in cases of resistance to NSCLC treatment, monitoring changes in tumor markers, and conducting a re-biopsy. Finally, we propose effective treatment measures for managing T-SCLC. |
| format | Article |
| id | doaj-art-322b76e88e3c4f56afc8bb0cd1c27858 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-322b76e88e3c4f56afc8bb0cd1c278582025-08-20T01:55:11ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-04-011510.3389/fonc.2025.15736241573624Case Report: Transforming small cell lung cancer: two cases report and literature reviewJinlong Liu0Jinlong Liu1Jing Ai2Jing Ai3Lize Zhao4Yimeng Qian5Yimeng Qian6Qingxin Zhao7Qingxin Zhao8Chunling Ma9Yu Zhao10Jing Zhao11Department of Oncology, Hebei General Hospital, Shijiazhuang, ChinaGraduate School, Hebei North University, Zhangjiakou, ChinaDepartment of Oncology, Hebei General Hospital, Shijiazhuang, ChinaGraduate School, North China University of Science and Technology, Tangshan, ChinaDepartment of Vascular Surgery, Hebei General Hospital, Shijiazhuang, ChinaDepartment of Oncology, Hebei General Hospital, Shijiazhuang, ChinaGraduate School, Hebei North University, Zhangjiakou, ChinaDepartment of Oncology, Hebei General Hospital, Shijiazhuang, ChinaGraduate School, Hebei North University, Zhangjiakou, ChinaDepartment of Oncology, Hebei General Hospital, Shijiazhuang, ChinaDepartment of Oncology, Hebei General Hospital, Shijiazhuang, ChinaDepartment of Oncology, Hebei General Hospital, Shijiazhuang, ChinaTransformation of non-small cell lung cancer (NSCLC) to small cell lung cancer (SCLC) is a relatively rare event with an incidence of about 3%-14%. Due to the poor treatment outcomes and prognosis associated with this transformation, understanding its underlying mechanisms is crucial for improving the diagnosis, management, and prognosis of transformed small cell lung cancer (T-SCLC). In this paper, we present two cases of T-SCLC and review the molecular mechanisms, clinical features, and treatment strategies post-transformation. We emphasize the importance of considering pathological transformation in cases of resistance to NSCLC treatment, monitoring changes in tumor markers, and conducting a re-biopsy. Finally, we propose effective treatment measures for managing T-SCLC.https://www.frontiersin.org/articles/10.3389/fonc.2025.1573624/fulltransformed small cell lung cancertumor markersre-biopsypathological transformationdrug resistance |
| spellingShingle | Jinlong Liu Jinlong Liu Jing Ai Jing Ai Lize Zhao Yimeng Qian Yimeng Qian Qingxin Zhao Qingxin Zhao Chunling Ma Yu Zhao Jing Zhao Case Report: Transforming small cell lung cancer: two cases report and literature review Frontiers in Oncology transformed small cell lung cancer tumor markers re-biopsy pathological transformation drug resistance |
| title | Case Report: Transforming small cell lung cancer: two cases report and literature review |
| title_full | Case Report: Transforming small cell lung cancer: two cases report and literature review |
| title_fullStr | Case Report: Transforming small cell lung cancer: two cases report and literature review |
| title_full_unstemmed | Case Report: Transforming small cell lung cancer: two cases report and literature review |
| title_short | Case Report: Transforming small cell lung cancer: two cases report and literature review |
| title_sort | case report transforming small cell lung cancer two cases report and literature review |
| topic | transformed small cell lung cancer tumor markers re-biopsy pathological transformation drug resistance |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1573624/full |
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