Decoding the enigmatic estrogen paradox in pulmonary hypertension: delving into estrogen metabolites and metabolic enzymes

Decoding the enigmatic estrogen paradox in pulmonary hypertension: delving into estrogen metabolites and metabolic enzymes

Abstract Pulmonary hypertension (PH) presents a puzzling sex bias, being more prevalent in women yet often less severe than in men, and the underlying reasons remain unclear. Studies using animal models, and limited clinical data have revealed a protective influence of exogenous estrogens, known as...

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Bibliographic Details
Main Authors: Qiang You, Hequn Song, Ziming Zhu, Jinzheng Wang, Ruixin Wang, Mingjia Du, Yingjie Fu, Jinxiang Yuan, Rubin Tan
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cellular & Molecular Biology Letters
Subjects:
Pulmonary hypertension
Estrogen
Hypoxia
Estrogen metabolites
CYPs
HSD17B
Online Access:https://doi.org/10.1186/s11658-024-00671-w
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