Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy
Glomerular VEGF expression is critical for the maintenance and function of an intact filtration barrier. Alterations in glomerular VEGF bioavailability result in endothelial as well as in podocyte damage. Renal involvement in preeclampsia includes proteinuria, podocyturia, elevated blood pressure, e...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2011/176973 |
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| _version_ | 1849306478583742464 |
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| author | Janina Müller-Deile Mario Schiffer |
| author_facet | Janina Müller-Deile Mario Schiffer |
| author_sort | Janina Müller-Deile |
| collection | DOAJ |
| description | Glomerular VEGF expression is critical for the maintenance and function of an intact filtration barrier. Alterations in glomerular VEGF bioavailability result in endothelial as well as in podocyte damage. Renal involvement in preeclampsia includes proteinuria, podocyturia, elevated blood pressure, edema, glomerular capillary endotheliosis, and thrombotic microangiopathy. At least the renal signs, symptoms, and other evidence can sufficiently be explained by reduced VEGF levels. The aim of this paper was to summarize our pathophysiological understanding of the renal involvement of preeclampsia and point out similarities to the renal side effects of VEGF-ablation therapy. |
| format | Article |
| id | doaj-art-322800a6d68e46e9be4cb971cc0ce141 |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-322800a6d68e46e9be4cb971cc0ce1412025-08-20T03:55:06ZengWileyJournal of Pregnancy2090-27272090-27352011-01-01201110.1155/2011/176973176973Renal Involvement in Preeclampsia: Similarities to VEGF Ablation TherapyJanina Müller-Deile0Mario Schiffer1Division of Nephrology and Hypertension, Department of Medicine, IFB-TX Hannover, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, GermanyDivision of Nephrology and Hypertension, Department of Medicine, IFB-TX Hannover, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, GermanyGlomerular VEGF expression is critical for the maintenance and function of an intact filtration barrier. Alterations in glomerular VEGF bioavailability result in endothelial as well as in podocyte damage. Renal involvement in preeclampsia includes proteinuria, podocyturia, elevated blood pressure, edema, glomerular capillary endotheliosis, and thrombotic microangiopathy. At least the renal signs, symptoms, and other evidence can sufficiently be explained by reduced VEGF levels. The aim of this paper was to summarize our pathophysiological understanding of the renal involvement of preeclampsia and point out similarities to the renal side effects of VEGF-ablation therapy.http://dx.doi.org/10.1155/2011/176973 |
| spellingShingle | Janina Müller-Deile Mario Schiffer Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy Journal of Pregnancy |
| title | Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy |
| title_full | Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy |
| title_fullStr | Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy |
| title_full_unstemmed | Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy |
| title_short | Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy |
| title_sort | renal involvement in preeclampsia similarities to vegf ablation therapy |
| url | http://dx.doi.org/10.1155/2011/176973 |
| work_keys_str_mv | AT janinamullerdeile renalinvolvementinpreeclampsiasimilaritiestovegfablationtherapy AT marioschiffer renalinvolvementinpreeclampsiasimilaritiestovegfablationtherapy |