Intestinal flora: a potential pathogenesis mechanism and treatment strategy for type 1 diabetes mellitus
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by destruction of pancreatic β-cells, leading to insulin deficiency and hyperglycemia, and its incidence is increasing year by year. The pathogenesis of T1DM is complex, mainly including genetic and environmental factors....
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2024.2423024 |
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| author | Shengnan Huang Fangfang Li Chunhua Quan Dan Jin |
| author_facet | Shengnan Huang Fangfang Li Chunhua Quan Dan Jin |
| author_sort | Shengnan Huang |
| collection | DOAJ |
| description | Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by destruction of pancreatic β-cells, leading to insulin deficiency and hyperglycemia, and its incidence is increasing year by year. The pathogenesis of T1DM is complex, mainly including genetic and environmental factors. Intestinal flora is the largest microbial community in the human body and plays a very important role in human health and disease. In recent years, more and more studies have shown that intestinal flora and its metabolites, as an environmental factor, regulate the development of T1DM through various mechanisms such as altering the intestinal mucosal barrier, influencing insulin secretion and body immune regulation. Intestinal flora transplantation, probiotic supplementation, and other approaches to modulate the intestinal flora appear to be potential therapeutic approaches for T1DM. This article reviews the dysbiosis of the intestinal flora in T1DM, the potential mechanisms by which the intestinal flora affects T1DM, as well as discusses potential approaches to treating T1DM by intervening in the intestinal flora. |
| format | Article |
| id | doaj-art-3227733c4e1c46aea4b8f167bc938b9f |
| institution | OA Journals |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-3227733c4e1c46aea4b8f167bc938b9f2025-08-20T02:05:28ZengTaylor & Francis GroupGut Microbes1949-09761949-09842024-12-0116110.1080/19490976.2024.2423024Intestinal flora: a potential pathogenesis mechanism and treatment strategy for type 1 diabetes mellitusShengnan Huang0Fangfang Li1Chunhua Quan2Dan Jin3Immunology Biology Key Laboratory, Yanbian University, Yanji, ChinaImmunology Biology Key Laboratory, Yanbian University, Yanji, ChinaCentral Laboratory, The Affiliated Hospital of Yanbian University, Yanji, ChinaImmunology Biology Key Laboratory, Yanbian University, Yanji, ChinaType 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by destruction of pancreatic β-cells, leading to insulin deficiency and hyperglycemia, and its incidence is increasing year by year. The pathogenesis of T1DM is complex, mainly including genetic and environmental factors. Intestinal flora is the largest microbial community in the human body and plays a very important role in human health and disease. In recent years, more and more studies have shown that intestinal flora and its metabolites, as an environmental factor, regulate the development of T1DM through various mechanisms such as altering the intestinal mucosal barrier, influencing insulin secretion and body immune regulation. Intestinal flora transplantation, probiotic supplementation, and other approaches to modulate the intestinal flora appear to be potential therapeutic approaches for T1DM. This article reviews the dysbiosis of the intestinal flora in T1DM, the potential mechanisms by which the intestinal flora affects T1DM, as well as discusses potential approaches to treating T1DM by intervening in the intestinal flora.https://www.tandfonline.com/doi/10.1080/19490976.2024.2423024Type 1 diabetes mellitusintestinal florashort-chain fatty acidsautoimmune disease |
| spellingShingle | Shengnan Huang Fangfang Li Chunhua Quan Dan Jin Intestinal flora: a potential pathogenesis mechanism and treatment strategy for type 1 diabetes mellitus Gut Microbes Type 1 diabetes mellitus intestinal flora short-chain fatty acids autoimmune disease |
| title | Intestinal flora: a potential pathogenesis mechanism and treatment strategy for type 1 diabetes mellitus |
| title_full | Intestinal flora: a potential pathogenesis mechanism and treatment strategy for type 1 diabetes mellitus |
| title_fullStr | Intestinal flora: a potential pathogenesis mechanism and treatment strategy for type 1 diabetes mellitus |
| title_full_unstemmed | Intestinal flora: a potential pathogenesis mechanism and treatment strategy for type 1 diabetes mellitus |
| title_short | Intestinal flora: a potential pathogenesis mechanism and treatment strategy for type 1 diabetes mellitus |
| title_sort | intestinal flora a potential pathogenesis mechanism and treatment strategy for type 1 diabetes mellitus |
| topic | Type 1 diabetes mellitus intestinal flora short-chain fatty acids autoimmune disease |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2024.2423024 |
| work_keys_str_mv | AT shengnanhuang intestinalfloraapotentialpathogenesismechanismandtreatmentstrategyfortype1diabetesmellitus AT fangfangli intestinalfloraapotentialpathogenesismechanismandtreatmentstrategyfortype1diabetesmellitus AT chunhuaquan intestinalfloraapotentialpathogenesismechanismandtreatmentstrategyfortype1diabetesmellitus AT danjin intestinalfloraapotentialpathogenesismechanismandtreatmentstrategyfortype1diabetesmellitus |