Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor-resistant tumors resulting in complete responses

Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor-resistant tumors resulting in complete responses

Abstract Despite the proven clinical activity of checkpoint inhibitors (ICIs) in several cancer indications, frequent occurrence of primary and secondary resistance reduces their overall effectiveness. Development of ICI resistance has been attributed mainly to genetic or epigenic alterations that a...

Full description

Saved in:
Bibliographic Details
Main Authors: Jayalakshmi Lakshmipathi, Sreevidya Santha, Man Li, Yuping Qian, Simon F. Roy, Nadia Luheshi, Katerina Politi, Marcus Bosenberg, Jim Eyles, Viswanathan Muthusamy
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Cancer Immunology, Immunotherapy
Subjects:
mRNA therapy
Intratumoral agent
Immunotherapy agent
Checkpoint resistance
Cytokine therapy
Online Access:https://doi.org/10.1007/s00262-025-04105-0
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items