Hybrid molecule SA-10 and its PLGA nanosuspension protect human and rodent retinal ganglion cells against neuronal injury

Hybrid molecule SA-10 and its PLGA nanosuspension protect human and rodent retinal ganglion cells against neuronal injury

Abstract Background Glaucoma is a leading cause of blindness characterized by retinal ganglion cell (RGC) degeneration. SA-10, a dual-acting compound with ROS scavenging and NO-donating properties, was evaluated to enhance RGC survival and function in models of oxidative stress, ischemia/reperfusion...

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Main Authors: Jennifer H. Pham, Wei Zhang, Kim-Tuyen T. Le, Bindu Kodati, Charles E. Amankwa, Biddut DebNath, Gretchen A. Johnson, Thien T. Bui, Rachel Y. Gitter, Jonah P. Gutierrez, Brendon R. Hatfield, Rojan Satyal, Ella R. Sinnott, Raghu R. Krishnamoorthy, Suchismita Acharya, Dorota L. Stankowska
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Neuroscience
Subjects:
Neuroprotection
Glaucoma
Retinal ganglion cells
Oxidative stress
Reactive oxygen species
Antioxidants
Online Access:https://doi.org/10.1186/s12868-025-00971-7
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